Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema
Joint Authors
Wanek, Justin
Lim, Jennifer I.
Shahidi, Mahnaz
Blair, Norman P.
Rangaraju, LakshmiPriya
Jiang, Xuejuan
McAnany, J. Jason
Tan, Michael R.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Diabetes is known to cause alterations in retinal microvasculature and tissue that progressively lead to visual impairment.
Optical coherence tomography (OCT) is useful for assessment of total retinal thickening due to diabetic macular edema (DME).
In the current study, we determined associations between visual acuity (VA) and retinal layer thickness, reflectance, and interface disruption derived from enface OCT images in subjects with and without DME.
Materials and Methods.
Best corrected VA was measured and high-density OCT volume scans were acquired in 149 diabetic subjects.
A previously established image segmentation method identified retinal layer interfaces and locations of visually indiscernible (disrupted) interfaces.
Enface thickness maps and reflectance images of the nerve fiber layer (NFL), combined ganglion cell and inner plexiform layer (GCLIPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor outer segment layer (OSL), and retinal pigment epithelium (RPE) were generated in the central macular subfield.
The associations among VA and retinal layer metrics were determined by multivariate linear regressions after adjusting for covariates (age, sex, race, HbA1c, diabetes type, and duration) and correcting for multiple comparisons.
Results.
In DME subjects, increased GCLIPL and OPL thickness and decreased OSL thickness were associated with reduced VA.
Furthermore, increased NFL reflectance and decreased OSL reflectance were associated with reduced VA.
Additionally, increased areas of INL and ONL interface disruptions were associated with reduced VA.
In subjects without DME, increased INL thickness was associated with reduced VA, whereas in subjects without DME but with previous antivascular endothelium growth factor treatment, thickening of OPL was associated with reduced VA.
Conclusions.
Alterations in retinal layer thickness and reflectance metrics derived from enface OCT images were associated with reduced VA with and without presence of DME, suggestive of their potential for monitoring development, progression, and treatment of DME.
American Psychological Association (APA)
Rangaraju, LakshmiPriya& Jiang, Xuejuan& McAnany, J. Jason& Tan, Michael R.& Wanek, Justin& Blair, Norman P.…[et al.]. 2018. Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196133
Modern Language Association (MLA)
Rangaraju, LakshmiPriya…[et al.]. Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema. Journal of Ophthalmology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1196133
American Medical Association (AMA)
Rangaraju, LakshmiPriya& Jiang, Xuejuan& McAnany, J. Jason& Tan, Michael R.& Wanek, Justin& Blair, Norman P.…[et al.]. Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196133
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196133