Mapping the Structure-Function Relationship in Glaucoma and Healthy Patients Measured with Spectralis OCT and Humphrey Perimetry
Joint Authors
Oblanca, Noelia
Jaumandreu, Laia
Rebolleda, Gema
Muñoz-Negrete, Francisco J.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Purpose.
To study the structure-function relationship in glaucoma and healthy patients assessed with Spectralis OCT and Humphrey perimetry using new statistical approaches.
Materials and Methods.
Eighty-five eyes were prospectively selected and divided into 2 groups: glaucoma (44) and healthy patients (41).
Three different statistical approaches were carried out: (1) factor analysis of the threshold sensitivities (dB) (automated perimetry) and the macular thickness (μm) (Spectralis OCT), subsequently applying Pearson’s correlation to the obtained regions, (2) nonparametric regression analysis relating the values in each pair of regions that showed significant correlation, and (3) nonparametric spatial regressions using three models designed for the purpose of this study.
Results.
In the glaucoma group, a map that relates structural and functional damage was drawn.
The strongest correlation with visual fields was observed in the peripheral nasal region of both superior and inferior hemigrids (r=0.602 and r=0.458, resp.).
The estimated functions obtained with the nonparametric regressions provided the mean sensitivity that corresponds to each given macular thickness.
These functions allowed for accurate characterization of the structure-function relationship.
Conclusions.
Both maps and point-to-point functions obtained linking structure and function damage contribute to a better understanding of this relationship and may help in the future to improve glaucoma diagnosis.
American Psychological Association (APA)
Jaumandreu, Laia& Muñoz-Negrete, Francisco J.& Oblanca, Noelia& Rebolleda, Gema. 2018. Mapping the Structure-Function Relationship in Glaucoma and Healthy Patients Measured with Spectralis OCT and Humphrey Perimetry. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1196163
Modern Language Association (MLA)
Jaumandreu, Laia…[et al.]. Mapping the Structure-Function Relationship in Glaucoma and Healthy Patients Measured with Spectralis OCT and Humphrey Perimetry. Journal of Ophthalmology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1196163
American Medical Association (AMA)
Jaumandreu, Laia& Muñoz-Negrete, Francisco J.& Oblanca, Noelia& Rebolleda, Gema. Mapping the Structure-Function Relationship in Glaucoma and Healthy Patients Measured with Spectralis OCT and Humphrey Perimetry. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1196163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196163