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Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke
Joint Authors
Hu, Wen-Long
Cheng, Yu-Chen
Sheen, Jer-Ming
Hung, Y.-C.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Good nutrition could maintain health and life.
Polyphenols are common nutrient mainly derived from fruits, vegetables, tea, coffee, cocoa, mushrooms, beverages, and traditional medicinal herbs.
They are potential substances against oxidative-related diseases, for example, cardiovascular disease, specifically, atherosclerosis-related ischemic heart disease and stroke, which are health and economic problems recognized worldwide.
In this study, we reviewed the risk factors for atherosclerosis, including hypertension, diabetes mellitus, hyperlipidemia, obesity, and cigarette smoking as well as the antioxidative activity of polyphenols, which could prevent the pathology of atherosclerosis, including endothelial dysfunction, low-density lipoprotein oxidation, vascular smooth muscle cell proliferation, inflammatory process by monocytes, macrophages or T lymphocytes, and platelet aggregation.
The strong radical-scavenging properties of polyphenols would exhibit antioxidative and anti-inflammation effects.
Polyphenols reduce ROS production by inhibiting oxidases, reducing the production of superoxide, inhibiting OxLDL formation, suppressing VSMC proliferation and migration, reducing platelet aggregation, and improving mitochondrial oxidative stress.
Polyphenol consumption also inhibits the development of hypertension, diabetes mellitus, hyperlipidemia, and obesity.
Despite the numerous in vivo and in vitro studies, more advanced clinical trials are necessary to confirm the efficacy of polyphenols in the treatment of atherosclerosis-related vascular diseases.
American Psychological Association (APA)
Cheng, Yu-Chen& Sheen, Jer-Ming& Hu, Wen-Long& Hung, Y.-C.. 2017. Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1196194
Modern Language Association (MLA)
Cheng, Yu-Chen…[et al.]. Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1196194
American Medical Association (AMA)
Cheng, Yu-Chen& Sheen, Jer-Ming& Hu, Wen-Long& Hung, Y.-C.. Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1196194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196194