![](/images/graphics-bg.png)
Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fafa)
Joint Authors
Pecháňová, Olga
Martinez, Maria Carmen
Agouni, Abdelali
Mostefai, Hadj Ahmed
Lagrue, Anne-Hélène
Sladkova, Martina
Rouet, Philippe
Desmoulin, Franck
Andriantsitohaina, Ramaroson
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of this work was to study the vascular effects of dietary supplementation of a nonalcoholic red wine polyphenol extract, Provinols, in Zucker fatty (ZF) obese rats.
ZF or lean rats received diet supplemented or not with Provinols for 8 weeks.
Vasoconstriction in response to phenylephrine (Phe) was then assessed in small mesenteric arteries (SMA) and the aorta with emphasis on the contribution of cyclooxygenases (COX).
Although no difference in vasoconstriction was observed between ZF and lean rats both in SMA and the aorta, Provinols affected the contribution of COX-derived vasoconstrictor agents.
The nonselective COX inhibitor, indomethacin, reduced vasoconstriction in vessels from both groups; however, lower efficacy was observed in Provinols-treated rats.
This was associated with a reduction in thromboxane-A2 and 8-isoprostane release.
The selective COX-2 inhibitor, NS398, reduced to the same extent vasoconstriction in aortas from ZF and Provinols-treated ZF rats.
However, NS398 reduced response to Phe only in SMA from ZF rats.
This was associated with a reduction in 8-isoprostane and prostaglandin-E release.
Paradoxically, Provinols decreased COX-2 expression in the aorta, while it increased its expression in SMA.
We provide here evidence of a subtle and paradoxical regulation of COX pathway by Provinols vessels from obese rats to maintain vascular tone within a physiological range.
American Psychological Association (APA)
Agouni, Abdelali& Mostefai, Hadj Ahmed& Lagrue, Anne-Hélène& Sladkova, Martina& Rouet, Philippe& Desmoulin, Franck…[et al.]. 2017. Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fafa). Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196204
Modern Language Association (MLA)
Agouni, Abdelali…[et al.]. Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fafa). Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1196204
American Medical Association (AMA)
Agouni, Abdelali& Mostefai, Hadj Ahmed& Lagrue, Anne-Hélène& Sladkova, Martina& Rouet, Philippe& Desmoulin, Franck…[et al.]. Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fafa). Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196204