Corneal Debridement Combined with Intrastromal Voriconazole for Recalcitrant Fungal Keratitis
Joint Authors
Sun, Zhuo
Deng, Guohua
Sun, Yajie
Chen, Yukai
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
To analyze the therapeutic effects of corneal debridement combined with intrastromal voriconazole in recalcitrant fungal keratitis.
Methods.
This is a retrospective study.
Fourteen patients with recalcitrant fungal keratitis were treated by corneal debridement combined with intrastromal voriconazole (50 μg/0.1 ml).
This paper reviews and analyzes the patients’ basic state, surgical intervention, medicinal treatment, and outcomes.
Results.
The mean sizes of infiltration and ulcer were (5.54 ± 1.32)mm and (3.46 ± 1.03)mm, respectively, and the mean depth was (315.43 ± 57.72)μm.
Twelve of the patients had satellite lesion, and 2 suffered hypopyon.
After intrastromal voriconazole, the size of infiltration decreased significantly to (4.32 ± 1.10)mm (P<0.001), but there was no significant change in ulcer size ((3.36 ± 0.92)mm, P=0.082).
Thirteen patients were cured after corneal debridement.
The mean healing time was (15.38 ± 7.38) days.
Excluding one cured patient with optic nerve atrophy and one patient for whom the treatment failed, the mean best-corrected visual acuity after healing was (0.23 ± 0.18)LogMAR, a significant improvement compared to pretreatment (0.87 ± 0.57(LogMAR), P=0.01).
The mean corneal astigmatism was (1.3 ± 1.6)D of 12 cured patients after healing and (1.0 ± 0.7)D at final follow-up, and there was no significant difference (P=0.374).
Conclusions.
Corneal debridement combined with intrastromal voriconazole is a secure and effective treatment for recalcitrant fungal keratitis.
American Psychological Association (APA)
Sun, Yajie& Sun, Zhuo& Chen, Yukai& Deng, Guohua. 2018. Corneal Debridement Combined with Intrastromal Voriconazole for Recalcitrant Fungal Keratitis. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196218
Modern Language Association (MLA)
Sun, Yajie…[et al.]. Corneal Debridement Combined with Intrastromal Voriconazole for Recalcitrant Fungal Keratitis. Journal of Ophthalmology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1196218
American Medical Association (AMA)
Sun, Yajie& Sun, Zhuo& Chen, Yukai& Deng, Guohua. Corneal Debridement Combined with Intrastromal Voriconazole for Recalcitrant Fungal Keratitis. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196218