Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System
Joint Authors
Yukitake, Hiroshi
Takizawa, Masayuki
Kimura, Haruhide
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Oxidative stress is involved in pathophysiology and pathological conditions of numerous human diseases.
Thus, understanding the mechanisms underlying the redox homeostasis in cells and organs is valuable for discovery of therapeutic drugs for oxidative stress-related diseases.
Recently, by applying chemical biology approach with an ARE activator, BTZO-1, we found macrophage migration inhibitory factor (MIF) as a new regulator of antioxidant response element- (ARE-) mediated gene transcription.
BTZO-1 and its active derivatives bound to MIF and protected cells and organs from oxidative insults via ARE activation in animal models with oxidative stress such as ischemia/reperfusion injury, inflammatory bowel diseases, and septic shock.
In this review, we briefly highlight key findings in understanding the MIF-ARE system.
American Psychological Association (APA)
Yukitake, Hiroshi& Takizawa, Masayuki& Kimura, Haruhide. 2017. Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1196224
Modern Language Association (MLA)
Yukitake, Hiroshi…[et al.]. Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1196224
American Medical Association (AMA)
Yukitake, Hiroshi& Takizawa, Masayuki& Kimura, Haruhide. Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1196224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196224