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Therapeutic Hypothermia Reduces Oxidative Damage and Alters Antioxidant Defenses after Cardiac Arrest
Joint Authors
Guerra, Maria Cristina
Hackenhaar, Fernanda S.
Medeiros, Tássia M.
Heemann, Fernanda M.
Behling, Camile S.
Putti, Jordana S.
Mahl, Camila D.
Verona, Cleber
da Silva, Ana Carolina A.
Oliveira, Vanessa M.
Riveiro, Diego F. M.
Vieira, Silvia R. R.
Benfato, Mara S.
Gonçalves, Carlos Alberto
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
After cardiac arrest, organ damage consequent to ischemia-reperfusion has been attributed to oxidative stress.
Mild therapeutic hypothermia has been applied to reduce this damage, and it may reduce oxidative damage as well.
This study aimed to compare oxidative damage and antioxidant defenses in patients treated with controlled normothermia versus mild therapeutic hypothermia during postcardiac arrest syndrome.
The sample consisted of 31 patients under controlled normothermia (36°C) and 11 patients treated with 24 h mild therapeutic hypothermia (33°C), victims of in- or out-of-hospital cardiac arrest.
Parameters were assessed at 6, 12, 36, and 72 h after cardiac arrest in the central venous blood samples.
Hypothermic and normothermic patients had similar S100B levels, a biomarker of brain injury.
Xanthine oxidase activity is similar between hypothermic and normothermic patients; however, it decreases posthypothermia treatment.
Xanthine oxidase activity is positively correlated with lactate and S100B and inversely correlated with pH, calcium, and sodium levels.
Hypothermia reduces malondialdehyde and protein carbonyl levels, markers of oxidative damage.
Concomitantly, hypothermia increases the activity of erythrocyte antioxidant enzymes superoxide dismutase, glutathione peroxidase, and glutathione S-transferase while decreasing the activity of serum paraoxonase-1.
These findings suggest that mild therapeutic hypothermia reduces oxidative damage and alters antioxidant defenses in postcardiac arrest patients.
American Psychological Association (APA)
Hackenhaar, Fernanda S.& Medeiros, Tássia M.& Heemann, Fernanda M.& Behling, Camile S.& Putti, Jordana S.& Mahl, Camila D.…[et al.]. 2017. Therapeutic Hypothermia Reduces Oxidative Damage and Alters Antioxidant Defenses after Cardiac Arrest. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196261
Modern Language Association (MLA)
Hackenhaar, Fernanda S.…[et al.]. Therapeutic Hypothermia Reduces Oxidative Damage and Alters Antioxidant Defenses after Cardiac Arrest. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1196261
American Medical Association (AMA)
Hackenhaar, Fernanda S.& Medeiros, Tássia M.& Heemann, Fernanda M.& Behling, Camile S.& Putti, Jordana S.& Mahl, Camila D.…[et al.]. Therapeutic Hypothermia Reduces Oxidative Damage and Alters Antioxidant Defenses after Cardiac Arrest. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196261