Histobiomechanical Remodeling of the Cervix during Pregnancy: Proposed Framework
Joint Authors
Torres, Jorge
Faris, Inas
Callejas, Antonio
Source
Mathematical Problems in Engineering
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Pregnancy involves a gradual change in tissue consistency, where, as gestational age increases a drop in stiffness is noticeable.
The extracellular matrix (ECM) of the cervix whose behavior is controlled by the collagen structure is reconfigured, due to hormonal and protein related factors that degraded it.
There is an increase in cellular and water content.
The collagen maintains a stable percentage, although the synthesis-solubility interaction causes a transformation in the network increasing its diameter and waviness, which destabilizes the mechanical integrity.
Further understanding of the remodeling of the cervix becomes a key element in the progress against preterm birth.
However, since the woman is in a very delicate state, the available information is scattered.
The aim is to provide a framework where the variation of the histological properties is linked with the individual biomechanical evolution of the constituents; therefore a multiscale approach to the problem can be made.
The results of different authors were reviewed to obtain values of each component depending on the gestational age, and then they were combined with the mechanical development of each variable obtained from the outputs of numerical simulations of another author.
An additive function is proposed, in which the mechanical contribution of each constituent is added to a reference value established for a nonpregnant state.
Results show how biochemistry models the mechanical behavior of the tissue through the histology and morphology of the ECM.
American Psychological Association (APA)
Torres, Jorge& Faris, Inas& Callejas, Antonio. 2019. Histobiomechanical Remodeling of the Cervix during Pregnancy: Proposed Framework. Mathematical Problems in Engineering،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1196299
Modern Language Association (MLA)
Torres, Jorge…[et al.]. Histobiomechanical Remodeling of the Cervix during Pregnancy: Proposed Framework. Mathematical Problems in Engineering No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1196299
American Medical Association (AMA)
Torres, Jorge& Faris, Inas& Callejas, Antonio. Histobiomechanical Remodeling of the Cervix during Pregnancy: Proposed Framework. Mathematical Problems in Engineering. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1196299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196299