Exercise Training under Exposure to Low Levels of Fine Particulate Matter: Effects on Heart Oxidative Stress and Extra-to-Intracellular HSP70 Ratio
Joint Authors
Heck, Thiago Gomes
Beber, Lílian Corrêa Costa
Frizzo, Matias Nunes
Ludwig, Mirna Stela
Rhoden, Cláudia Ramos
Mai, Aline Sfalcin
dos Santos, Analu Bender
Basso, Renan Daniel Bueno
Sulzbacher, Lucas Machado
Goettems-Fiorin, Pauline Brendler
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Fine particulate matter (PM2.5) promotes heart oxidative stress (OS) and evokes anti-inflammatory responses observed by increased intracellular 70 kDa heat shock proteins (iHSP70).
Furthermore, PM2.5 increases the levels of these proteins in extracellular fluids (eHSP70), which have proinflammatory roles.
We investigated whether moderate and high intensity training under exposure to low levels of PM2.5 modifies heart OS and the eHSP70 to iHSP70 ratio (H-index), a biomarker of inflammatory status.
Male mice (n=32), 30 days old, were divided into six groups for 12 weeks: control (CON), moderate (MIT) and high intensity training (HIT), exposure to 5 μg of PM2.5 daily (PM2.5), and moderate and high intensity training exposed to PM2.5 (MIT + PM2.5 and HIT + PM2.5 groups).
The CON and PM2.5 groups remained sedentary.
The MIT + PM2.5 group showed higher heart lipid peroxidation levels than the MIT and PM2.5 groups.
HIT and HIT + PM2.5 showed higher heart lipid peroxidation levels and lower eHSP70 and H-index levels compared to sedentary animals.
No alterations were found in heart antioxidant enzyme activity or iHSP70 levels.
Moderate exercise training under exposure to low levels of PM2.5 induces heart OS but does not modify eHSP70 to iHSP70 ratio (H-index).
High intensity exercise training promotes anti-inflammatory profile despite exposure to low levels of PM2.5.
American Psychological Association (APA)
Mai, Aline Sfalcin& dos Santos, Analu Bender& Beber, Lílian Corrêa Costa& Basso, Renan Daniel Bueno& Sulzbacher, Lucas Machado& Goettems-Fiorin, Pauline Brendler…[et al.]. 2017. Exercise Training under Exposure to Low Levels of Fine Particulate Matter: Effects on Heart Oxidative Stress and Extra-to-Intracellular HSP70 Ratio. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1196338
Modern Language Association (MLA)
Mai, Aline Sfalcin…[et al.]. Exercise Training under Exposure to Low Levels of Fine Particulate Matter: Effects on Heart Oxidative Stress and Extra-to-Intracellular HSP70 Ratio. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1196338
American Medical Association (AMA)
Mai, Aline Sfalcin& dos Santos, Analu Bender& Beber, Lílian Corrêa Costa& Basso, Renan Daniel Bueno& Sulzbacher, Lucas Machado& Goettems-Fiorin, Pauline Brendler…[et al.]. Exercise Training under Exposure to Low Levels of Fine Particulate Matter: Effects on Heart Oxidative Stress and Extra-to-Intracellular HSP70 Ratio. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1196338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196338