Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy
Joint Authors
Fawzy, Samah M.
Rashad, Mohammad Ahmad
Abdel Latif, Ahmed Abdel Meguid
Mostafa, Hazem A.
Abdel Latif, Mahmoud Abdel Meguid
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Investigating the efficacy of intravitreal injection of erythropoietin (EPO) in managing indirect traumatic optic neuropathy (ITON) of different durations.
Methods.
A case series that included two groups of ITON patients: recent ITON group (<3 months trauma duration; 7 eyes) and old duration ITON group (3–36 months; 7 eyes).
Diagnostic computerized tomography (CT) and baseline flash visual evoked response (VER) were performed at the presentation time.
At the initial visit and each follow-up, all patients had undergone assessment of best-corrected visual acuity (BCVA), pupil reaction, and anterior and posterior segments.
VER was repeated 1 and 3 months after injection.
All patients received an intravitreal injection of 2000 IU EPO in 0.2 ml of commercially available sterile EPREX 4000 solution, Jansen Cilag, Zug, Switzerland.
Five patients had received a second injection 3 months later.
Results.
Significant improvement was found in BCVA, VER amplitude, and latency (P<0.0001, 0.0154, and 0.0291, respectively).
Initial values of BCVA, VER amplitude, and latency correlated significantly to the final values.
Differences between recent and old trauma groups were insignificant in the three parameters.
In patients who received second injection, further clinical but statistically insignificant improvement was noted in BCVA in 60% of patients, VER amplitude in 50% of patients, and in VER latency in 100% of patients.
No complications were recorded.
Conclusion.
Intravitreal injection of EPO may be effective and safe in treatment of recent and old indirect traumatic optic neuropathy.
American Psychological Association (APA)
Rashad, Mohammad Ahmad& Abdel Latif, Ahmed Abdel Meguid& Mostafa, Hazem A.& Fawzy, Samah M.& Abdel Latif, Mahmoud Abdel Meguid. 2018. Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1196361
Modern Language Association (MLA)
Rashad, Mohammad Ahmad…[et al.]. Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy. Journal of Ophthalmology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1196361
American Medical Association (AMA)
Rashad, Mohammad Ahmad& Abdel Latif, Ahmed Abdel Meguid& Mostafa, Hazem A.& Fawzy, Samah M.& Abdel Latif, Mahmoud Abdel Meguid. Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1196361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196361