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Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress
Joint Authors
Popoli, Maurizio
Tremoli, Elena
Ieraci, Alessandro
Sandrini, Leonardo
Amadio, Patrizia
Barbieri, Silvia S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Environmental chronic stress (ECS) has been identified as a trigger of acute coronary syndromes (ACS).
Changes in redox balance, enhanced reactive oxygen species (ROS) production, and platelet hyperreactivity were detected in both ECS and ACS.
However, the mechanisms by which ECS predisposes to thrombosis are not fully understood.
Here, we investigated the impact of ECS on platelet activation and megakaryopoiesis in mice and the effect of Apocynin in this experimental setting.
ECS induced by 4 days of forced swimming stress (FSS) treatment predisposed to arterial thrombosis and increased oxidative stress (e.g., plasma malondialdehyde levels).
Interestingly, Apocynin treatment prevented these alterations.
In addition, FSS induced abnormal megakaryopoiesis increasing the number and the maturation state of bone marrow megakaryocytes (MKs) and affecting circulating platelets.
In particular, a higher number of large and reticulated platelets with marked functional activation were detected after FSS.
Apocynin decreased the total MK number and prevented their ability to generate ROS without affecting the percentage of CD42d+ cells, and it reduced the platelet hyperactivation in stressed mice.
In conclusion, Apocynin restores the physiological megakaryopoiesis and platelet behavior, preventing the detrimental effect of chronic stress on thrombosis, suggesting its potential use in the occurrence of thrombosis associated with ECS.
American Psychological Association (APA)
Sandrini, Leonardo& Ieraci, Alessandro& Amadio, Patrizia& Popoli, Maurizio& Tremoli, Elena& Barbieri, Silvia S.. 2017. Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196410
Modern Language Association (MLA)
Sandrini, Leonardo…[et al.]. Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1196410
American Medical Association (AMA)
Sandrini, Leonardo& Ieraci, Alessandro& Amadio, Patrizia& Popoli, Maurizio& Tremoli, Elena& Barbieri, Silvia S.. Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196410