Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer’s Disease
Joint Authors
Martín-Maestro, Patricia
Gargini, Ricardo
García, Esther
Avila, Jesús
García-Escudero, Vega
Perry, George
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Sporadic Alzheimer’s disease corresponds to 95% of cases whose origin is multifactorial and elusive.
Mitochondrial dysfunction is a major feature of Alzheimer’s pathology, which might be one of the early events that trigger downstream principal events.
Here, we show that multiple genes that control mitochondrial homeostasis, including fission and fusion, are downregulated in Alzheimer’s patients.
Additionally, we demonstrate that some of these dysregulations, such as diminished DLP1 levels and its mitochondrial localization, as well as reduced STOML2 and MFN2 fusion protein levels, take place in fibroblasts from sporadic Alzheimer’s disease patients.
The analysis of mitochondrial network disruption using CCCP indicates that the patients’ fibroblasts exhibit slower dynamics and mitochondrial membrane potential recovery.
These defects lead to strong accumulation of aged mitochondria in Alzheimer’s fibroblasts.
Accordingly, the analysis of autophagy and mitophagy involved genes in the patients demonstrates a downregulation indicating that the recycling mechanism of these aged mitochondria might be impaired.
Our data reinforce the idea that mitochondrial dysfunction is one of the key early events of the disease intimately related with aging.
American Psychological Association (APA)
Martín-Maestro, Patricia& Gargini, Ricardo& García, Esther& Perry, George& Avila, Jesús& García-Escudero, Vega. 2017. Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1196442
Modern Language Association (MLA)
Martín-Maestro, Patricia…[et al.]. Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1196442
American Medical Association (AMA)
Martín-Maestro, Patricia& Gargini, Ricardo& García, Esther& Perry, George& Avila, Jesús& García-Escudero, Vega. Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1196442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196442