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Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2
Joint Authors
Guan, Cuiping
Li, Qingtian
Song, Xiuzu
Xu, Wen
Li, Liuyu
Xu, Aie
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Antroquinonol was investigated as antioxidant and inhibition of inflammatory responses.
Our study was to evaluate its immunosuppressive effect on CD8+ T cells and protective effect on depigmentation.
CD8+ T cells were treated with antroquinonol in vitro, and C57BL/6 mice were treated with antroquinonol with or without H2O2 in vivo for 50 consecutive days.
We found antroquinonol could inhibit proliferation of CD8+ T cells and suppress the production of cytokines IL-2 and IFN-γ and T cell activation markers CD69 and CD137 in vitro.
H2O2 treatment induced depigmentation and reduced hair follicle length, skin thickness, and tyrosinase expression in vivo.
Whereas, antroquinonol obviously ameliorated depigmentation of mice skin and resisted the reduction of hair follicle length, skin thickness, and tyrosinase expression induced by H2O2.
Antroquinonol decreased CD8+ T cell infiltration in mice skin, inhibited the production of IL-2 and IFN-γ, and decreased the expression of CXCL10 and CXCR3.
Summarily, our data shows antroquinonol inhibits CD8+ T cell proliferation in vitro.
It also reduces CD8+ T cell infiltration and proinflammatory cytokine secretion and suppresses the thinning of epidermal layer in vivo.
Our findings suggest that antroquinonol exerts immunosuppressive effects on CD8+ T cell proliferation and activation to resist depigmentation induced by H2O2.
American Psychological Association (APA)
Guan, Cuiping& Li, Qingtian& Song, Xiuzu& Xu, Wen& Li, Liuyu& Xu, Aie. 2017. Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1196462
Modern Language Association (MLA)
Guan, Cuiping…[et al.]. Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1196462
American Medical Association (AMA)
Guan, Cuiping& Li, Qingtian& Song, Xiuzu& Xu, Wen& Li, Liuyu& Xu, Aie. Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1196462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196462