Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis
Joint Authors
Abdeltawab, Nourtan F.
El-Boghdady, Noha A.
Nooh, Mohammed M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Paraquat (PQ) is one of the most used herbicide worldwide.
Its cytotoxicity is attributed to reactive radical generation.
Resveratrol (Res) and montelukast (MK) have anti-inflammatory and antioxidant properties.
The protective effects of Res, MK, or their combination against PQ-induced acute liver injury have not been investigated before.
Therefore, we explored the protective potential of Res and/or MK against PQ hepatic toxicity in a mouse model.
Mice were randomly assigned to five groups: group I served as the normal control and group II received a single dose of PQ (50 mg/kg, i.p.).
Groups III, IV, and V received PQ plus oral Res (5 mg/kg/day), MK (10 mg/kg/day), and Res/MK combination, respectively.
Res and/or MK reduced PQ-induced liver injury, evidenced by normalization of serum total protein, ALT, and AST.
Res and/or MK significantly reversed PQ-induced oxidative stress markers glutathione and malondialdehyde.
Res and/or MK significantly reduced PQ-induced inflammation reflected in TNF-α levels.
Furthermore, Res and/or MK reversed PQ-induced apoptosis assessed by differential expression of p53, Bax, and Bcl-2.
Histopathologic examination supported the biochemical findings.
Although Res and MK displayed antioxidative, anti-inflammatory, and antiapoptotic activities, their combination was not always synergistic.
American Psychological Association (APA)
El-Boghdady, Noha A.& Abdeltawab, Nourtan F.& Nooh, Mohammed M.. 2017. Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1196507
Modern Language Association (MLA)
El-Boghdady, Noha A.…[et al.]. Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1196507
American Medical Association (AMA)
El-Boghdady, Noha A.& Abdeltawab, Nourtan F.& Nooh, Mohammed M.. Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1196507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196507