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Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract
Joint Authors
Yang, Mei
Kang, Lihua
Shen, Xinyue
Zhu, Manhui
Tu, Yuanyuan
Li, Lele
Zhang, Rutan
Qin, Bai
Guan, Huaijin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Lanosterol synthase (LSS) abnormity contributes to lens opacity in rats, mice, dogs, and human congenital cataract development.
This study examined whether LSS pathway has a role in different subtypes of age-related cataract (ARC).
Methods.
A total of 390 patients with ARC and 88 age-matched non-ARC patients were enrolled in this study.
LSS expression was analyzed by western blot and enzyme-linked immunosorbent assay (ELISA).
To further examine the function of LSS, we used U18666A, an LSS inhibitor in rat lens culture system.
Results.
In lens epithelial cells (LECs), LSS expression in LECs increased with opaque degree C II, while it decreased with opaque degree C IV and C V.
While in the cortex of age-related cortical cataract (ARCC), LSS expression was negatively related to opaque degree, while lanosterol level was positively correlated to opaque degree.
No obvious change in both LSS and lanosterol level was found in either LECs or the cortex of age-related nuclear cataract (ARNC) and age-related posterior subcapsular cataract (ARPSC).
In vitro, inhibiting LSS activity induced rat lens opacity and lanosterol effectively delayed the occurrence of lens opacity.
Conclusions.
This study indicated that LSS and lanosterol were localized in the lens of human ARC, including ARCC, ARNC, and ARPSC.
LSS and lanosterol level are only correlated with opaque degree of ARCC.
Furthermore, activated LSS pathway in lens is protective for lens transparency in cortical cataract.
American Psychological Association (APA)
Shen, Xinyue& Zhu, Manhui& Kang, Lihua& Tu, Yuanyuan& Li, Lele& Zhang, Rutan…[et al.]. 2018. Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1196525
Modern Language Association (MLA)
Shen, Xinyue…[et al.]. Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract. Journal of Ophthalmology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1196525
American Medical Association (AMA)
Shen, Xinyue& Zhu, Manhui& Kang, Lihua& Tu, Yuanyuan& Li, Lele& Zhang, Rutan…[et al.]. Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1196525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196525