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Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial
Joint Authors
Queiroz-Hazarbassanov, Nicolle
Hazarbassanov, R. M.
Barros, J. N.
Gomes, J. A. P.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Dry eye disease (DED) is one of the most common complications following refractive surgery.
Purpose.
Evaluate the efficacy of an osmoprotective eye drop (Optive®) for the management of induced DED in refractive surgery patients.
Design.
Double-masked randomised controlled trial.
Methods.
Twenty-two refractive surgery patients oriented to apply FreshTears (FT; n=13) or Optive (Op; n=9), topically, QID, for 3 months.
Eye exams were performed before surgery (T0) and 1-month (T1) and 3-month (T3) follow-up and consisted of tear film osmolarity, Schirmer 1 test, tear film breakup time (TBUT), fluorescein staining, and ocular surface disease index (OSDI) and patient symptoms questionnaires.
Main Outcome Measures.
Pain and osmolarity.
Results.
Pain increased significantly for FT at T3 (p<0.05).
A reduction in osmolarity was observed at T1 and T3 for Op group (p<0.01) and at T3 for FT group (p<0.05).
TBUT showed a decrease between T0 and T1 for FT (p<0.05).
Schirmer 1 values increased significantly for Op in T1.
Conclusions.
Op was superior to FT in regard to pain, osmolarity, TBUT, and Schirmer 1.
Osmoprotectant solutes, such as L-carnitine, could attenuate inflammation and secondary DED.
Osmoprotective lubricants can be effectively applied for the prevention of refractive surgery-related dry eye symptoms and signs.
American Psychological Association (APA)
Hazarbassanov, R. M.& Queiroz-Hazarbassanov, Nicolle& Barros, J. N.& Gomes, J. A. P.. 2018. Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1196550
Modern Language Association (MLA)
Hazarbassanov, R. M.…[et al.]. Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial. Journal of Ophthalmology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1196550
American Medical Association (AMA)
Hazarbassanov, R. M.& Queiroz-Hazarbassanov, Nicolle& Barros, J. N.& Gomes, J. A. P.. Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1196550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196550