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Cardiovascular Protective Effects of Salvianic Acid A on dbdb Mice with Elevated Homocysteine Level
Joint Authors
Siu, Parco M.
Lai, Christopher W. K.
Gao, Lei
Chan, Shun-Wan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The onsets of left ventricular hypertrophy (LVH) and endothelial dysfunction (ED) in diabetics, especially in those with elevated homocysteine (Hcy), precede the development of cardiovascular (CV) events.
Salvianic acid A (SAA) is a renowned Traditional Chinese Medicine (TCM) that has been applied in the treatment of cardiovascular disease for many decades.
In this study, we aimed (1) to investigate the CV protective effects of SAA on ameliorating LVH and ED in db/db mice with elevated blood Hcy level and (2) to decipher whether the observed CV protective effects of SAA are associated with Hcy metabolism by modulating the methylation potential and redox status in the liver of the db/db mice with elevated blood Hcy level.
Our results found that the administration of SAA could significantly slow down the build-up of left ventricular mass and ameliorate ED.
Immunological assay analysis on the mouse liver tissue also indicated that SAA treatment on db/db mice with elevated Hcy was associated with reduced methylation potential but improved redox status.
In conclusion, we revealed that SAA has the potential to protect against the hyperglycemia- and hyperhomocysteinemia-induced oxidative stress on diabetic mice via modulation in Hcy metabolism.
American Psychological Association (APA)
Gao, Lei& Siu, Parco M.& Chan, Shun-Wan& Lai, Christopher W. K.. 2017. Cardiovascular Protective Effects of Salvianic Acid A on dbdb Mice with Elevated Homocysteine Level. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196575
Modern Language Association (MLA)
Gao, Lei…[et al.]. Cardiovascular Protective Effects of Salvianic Acid A on dbdb Mice with Elevated Homocysteine Level. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1196575
American Medical Association (AMA)
Gao, Lei& Siu, Parco M.& Chan, Shun-Wan& Lai, Christopher W. K.. Cardiovascular Protective Effects of Salvianic Acid A on dbdb Mice with Elevated Homocysteine Level. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196575