Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration
Joint Authors
Takayama, Kei
Kaneko, Hiroki
Kataoka, Keiko
Hwang, Shiang-Jyi
Ye, Fuxiang
Nagasaka, Yosuke
Tsunekawa, Taichi
Matsuura, Toshiyuki
Ito, Yasuki
Terasaki, Hiroko
Fukukita, Hiroshi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To compare serum levels of malondialdehyde (MDA) in patients with wet age-related macular degeneration (wAMD), patients with dry AMD (dAMD), and patients without AMD and to evaluate the efficacy of nutritional supplementation for treating elevated serum MDA in patients with wAMD.
Methods.
MDA levels were measured in sera from 20 patients with wAMD, 20 with dAMD, and 24 without AMD.
Patients with wAMD were randomized to receive or not receive nutritional supplementation (10 patients in each group), and MDA levels were measured after 3 months of treatment.
Results.
MDA levels in patients with wAMD were significantly greater compared with patients without AMD.
In eyes with wAMD, there was a significant correlation between MDA levels and choroidal neovascularization lesion area.
Serum MDA levels decreased in most patients that received supplementation and significantly increased in those who did not.
Conclusion.
Baseline serum MDA levels were elevated in patients with wAMD, and MDA levels were directly correlated with choroidal neovascularization lesion area.
In addition, nutritional supplementation appeared to exert a protective effect against oxidative stress in patients with wAMD.
American Psychological Association (APA)
Matsuura, Toshiyuki& Takayama, Kei& Kaneko, Hiroki& Ye, Fuxiang& Fukukita, Hiroshi& Tsunekawa, Taichi…[et al.]. 2017. Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1196597
Modern Language Association (MLA)
Matsuura, Toshiyuki…[et al.]. Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1196597
American Medical Association (AMA)
Matsuura, Toshiyuki& Takayama, Kei& Kaneko, Hiroki& Ye, Fuxiang& Fukukita, Hiroshi& Tsunekawa, Taichi…[et al.]. Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1196597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196597