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Effect of Hyaluronic AcidTrehalose in Two Different Formulations on Signs and Symptoms in Patients with Moderate to Severe Dry Eye Disease
Joint Authors
Popa-Cherecheanu, Alina
Schmetterer, Leopold
Garhöfer, Gerhard
Witkowska, Katarzyna J.
Fondi, Klemens
Wozniak, Piotr A.
Schmidl, Doreen
Bata, Ahmed M.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
This randomized, observer-masked, crossover study investigated the effect of two hyaluronic acid/trehalose-based containing formulations, with different physical properties, on the signs and symptoms in patients with moderate to severe dry eye disease (DED).
Methods.
In one group, patients received a mixture of sodium hyaluronate and trehalose (HT, Thealoz Duo®) for use during the day.
In the other group, patients received a more viscous formulation consisting of hyaluronic acid, trehalose, and carbomer (HTC-gel, Thealoz Duo Gel) to use pro re nata.
Both groups used HTC-gel before going to bed.
Clinical standard tests for DED were performed at the beginning and end of each one-week period.
Further, patient satisfaction including quality of sleep was assessed using a visual analogue scale.
Results.
Corneal fluorescein and conjunctival lissamine green staining scores decreased, and tear breakup time (BUT) increased for both groups (p<0.001 each).
Mean instillation frequency was 3.1 ± 2.6 drops/day when using HT and 1.9 ± 2.2 drops/day when using HTC-gel (p=0.02).
A significant improvement in the quality of sleep was observed with both treatments (p=0.01).
Conclusions.
Our results show improvement in signs and symptoms of DED in both groups.
While instillation of HTC-gel resulted in a lower instillation frequency, both formulations of trehalose showed good clinical efficacy.
This trial is registered with NCT02980913.
American Psychological Association (APA)
Fondi, Klemens& Wozniak, Piotr A.& Schmidl, Doreen& Bata, Ahmed M.& Witkowska, Katarzyna J.& Popa-Cherecheanu, Alina…[et al.]. 2018. Effect of Hyaluronic AcidTrehalose in Two Different Formulations on Signs and Symptoms in Patients with Moderate to Severe Dry Eye Disease. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1196603
Modern Language Association (MLA)
Fondi, Klemens…[et al.]. Effect of Hyaluronic AcidTrehalose in Two Different Formulations on Signs and Symptoms in Patients with Moderate to Severe Dry Eye Disease. Journal of Ophthalmology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1196603
American Medical Association (AMA)
Fondi, Klemens& Wozniak, Piotr A.& Schmidl, Doreen& Bata, Ahmed M.& Witkowska, Katarzyna J.& Popa-Cherecheanu, Alina…[et al.]. Effect of Hyaluronic AcidTrehalose in Two Different Formulations on Signs and Symptoms in Patients with Moderate to Severe Dry Eye Disease. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1196603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196603