Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice
Joint Authors
Nemmar, Abderrahim
Yuvaraju, Priya
Beegam, Sumaya
Fahim, Mohamed A.
Ali, Badreldin H.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
CeO2 nanoparticles (CeO2 NPs) which are used as a diesel fuel additive are emitted in the particulate phase in the exhaust, posing a health concern.
However, limited information exists regarding the in vivo acute toxicity of CeO2 NPs on multiple organs.
Presently, we investigated the acute (24 h) effects of intratracheally instilled CeO2 NPs in mice (0.5 mg/kg) on oxidative stress, inflammation, and DNA damage in major organs including lung, heart, liver, kidneys, spleen, and brain.
Lipid peroxidation measured by malondialdehyde production was increased in the lungs only, and reactive oxygen species were increased in the lung, heart, kidney, and brain.
Superoxide dismutase activity was decreased in the lung, liver, and kidney, whereas glutathione increased in lung but it decreased in the kidney.
Total nitric oxide was increased in the lung and spleen but it decreased in the heart.
Tumour necrosis factor-α increased in all organs studied.
Interleukin- (IL-) 6 increased in the lung, heart, liver, kidney, and spleen.
IL-1β augmented in the lung, heart, kidney, and spleen.
Moreover, CeO2 NPs induced DNA damage, assessed by COMET assay, in all organs studied.
Collectively, these findings indicate that pulmonary exposure to CeO2 NPs causes oxidative stress, inflammation, and DNA damage in multiple organs.
American Psychological Association (APA)
Nemmar, Abderrahim& Yuvaraju, Priya& Beegam, Sumaya& Fahim, Mohamed A.& Ali, Badreldin H.. 2017. Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196612
Modern Language Association (MLA)
Nemmar, Abderrahim…[et al.]. Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1196612
American Medical Association (AMA)
Nemmar, Abderrahim& Yuvaraju, Priya& Beegam, Sumaya& Fahim, Mohamed A.& Ali, Badreldin H.. Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196612