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Efficacy and Safety of Intravitreal Conbercept, Ranibizumab, and Triamcinolone on 23-Gauge Vitrectomy for Patients with Proliferative Diabetic Retinopathy
Joint Authors
Charles, Steve
Cui, Jinglin
Chen, Hong
Lu, Hang
Dong, Fangtian
Wei, Dongmei
Wang, Lin
Jiao, Yan
Gu, Weikuan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
To compare the effect and safety of intravitreal conbercept (IVC), intravitreal ranibizumab (IVR), or intravitreal triamcinolone acetonide (IVTA) injection on 23-gauge (23-G) pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR).
Methods.
Fifty patients (60 eyes) of varying degrees of PDR were randomly grouped into 3 groups (1 : 1 : 1) (n=20 in each group).
The 23-G PPV was performed with intravitreal conbercept or ranibizumab injection 3–7 days before surgery or intravitreal TA injection during surgery.
The experiment was randomized controlled, with a noninferiority limit of five letters.
Main outcome measures included BCVA, operation time, incidence of iatrogenic retinal breaks, endodiathermy rate, and silicone oil tamponade.
Results.
At 6 months after surgery, there were no significant differences of BCVA improvements, operation time, incidence of iatrogenic retinal breaks, endodiathermy rate, silicone oil tamponade, vitreous clear-up time, and the incidence of intraoperative bleeding between the IVC and IVR groups (all P values ≥ 0.05), but they were significantly different from the IVTA group (all P values < 0.05).
IOP increases did not show significant differences between the IVC and IVR groups, but both were significantly different with the IVTA group.
More patients had higher postoperative IOP in the IVTA group.
Conclusions.
The intravitreal injection of conbercept, ranibizumab, or TA for PDR had a significant different effect on outcomes of 23-G PPV surgery.
Conbercept and ranibizumab can reduce difficulty of the operation, improve the success rate of PPV surgery, and decrease the incidence of postoperative complications.
American Psychological Association (APA)
Cui, Jinglin& Chen, Hong& Lu, Hang& Dong, Fangtian& Wei, Dongmei& Jiao, Yan…[et al.]. 2018. Efficacy and Safety of Intravitreal Conbercept, Ranibizumab, and Triamcinolone on 23-Gauge Vitrectomy for Patients with Proliferative Diabetic Retinopathy. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1196625
Modern Language Association (MLA)
Cui, Jinglin…[et al.]. Efficacy and Safety of Intravitreal Conbercept, Ranibizumab, and Triamcinolone on 23-Gauge Vitrectomy for Patients with Proliferative Diabetic Retinopathy. Journal of Ophthalmology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1196625
American Medical Association (AMA)
Cui, Jinglin& Chen, Hong& Lu, Hang& Dong, Fangtian& Wei, Dongmei& Jiao, Yan…[et al.]. Efficacy and Safety of Intravitreal Conbercept, Ranibizumab, and Triamcinolone on 23-Gauge Vitrectomy for Patients with Proliferative Diabetic Retinopathy. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1196625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196625