HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases
Joint Authors
Zhou, Xuezhi
Liu, Yi
Zhuang, Guo-Bin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
High-mobility group box 1 (HMGB1) is a nuclear protein that can also act as an extracellular trigger of inflammation, proliferation, and migration in eye diseases.
It induces signaling pathways by binding to the receptor for advanced glycation end products (RAGE) and Toll-like receptors (TLRs) 2, 4, and 9.
This proinflammatory activity is considered to be important in the pathogenesis of a wide range of ocular diseases resulting from hemodynamic changes, presence of neovascular endothelial cells, secretion of intraocular immune factors or inflammation, and apoptosis of retinal cell layers.
Further work is needed to elucidate in detail how HMGB1 contributes to ocular disease and how its damaging activity can be modulated.
In this review, we summarize current knowledge on HMGB1 as a ligand that can evoke inflammation and immune responses in ocular diseases.
American Psychological Association (APA)
Liu, Yi& Zhuang, Guo-Bin& Zhou, Xuezhi. 2018. HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196642
Modern Language Association (MLA)
Liu, Yi…[et al.]. HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases. Journal of Ophthalmology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1196642
American Medical Association (AMA)
Liu, Yi& Zhuang, Guo-Bin& Zhou, Xuezhi. HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196642