The Balance of Th1Th2 and LAP+TregsTh17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation
Joint Authors
Pan, Zhiqiang
Li, Shang
Jie, Ying
Yu, Jing
Guo, Chungang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
CD4+LAP+ T cells are newly discovered regulatory T cells (Tregs).
The aim of this study is to investigate the balance of Th1/Th2 and LAP+Tregs/Th17 in mice after allogeneic corneal transplantation.
Methods.
A total of 65 mice received orthotopic penetrating transplantation.
According to the survival scores of the grafts, the mice were divided into the rejection group and the survival group 3 weeks after transplantation.
Th1, Th2, Th17, and regulatory T cells in the ipsilateral drainage lymph nodes and spleens were measured with flow cytometry.
The related cytokines in aqueous humor were also analyzed.
Results.
The frequencies of Foxp3+Tregs, GARP+Tregs, and LAP+Tregs in the survival group were significantly higher than those in the rejection group.
And the expression trend of CD4+LAP+ T cells and CD4+GARP+ T cells was consistent.
The level of IFN-γ, TNF, IL-6, and IL-17A markedly increased in aqueous humor during corneal allograft rejection.
The ratio of Th1/Th2 and Th17/LAP+Tregs significantly increased in the rejection group at the 3rd week after corneal transplantation.
Conclusion.
LAP+Tregs might be regarded as substitute for Foxp3+Tregs.
The balance of Th1/Th2 and LAP+Tregs/Th17 is crucial for corneal allograft survival.
American Psychological Association (APA)
Li, Shang& Yu, Jing& Guo, Chungang& Jie, Ying& Pan, Zhiqiang. 2018. The Balance of Th1Th2 and LAP+TregsTh17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1196672
Modern Language Association (MLA)
Li, Shang…[et al.]. The Balance of Th1Th2 and LAP+TregsTh17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation. Journal of Ophthalmology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1196672
American Medical Association (AMA)
Li, Shang& Yu, Jing& Guo, Chungang& Jie, Ying& Pan, Zhiqiang. The Balance of Th1Th2 and LAP+TregsTh17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1196672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196672