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Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease
Joint Authors
Manzanares-Estreder, Sara
Pascual-Ahuir, Amparo
Proft, Markus
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Peroxisomes and mitochondria are the main intracellular sources for reactive oxygen species.
At the same time, both organelles are critical for the maintenance of a healthy redox balance in the cell.
Consequently, failure in the function of both organelles is causally linked to oxidative stress and accelerated aging.
However, it has become clear that peroxisomes and mitochondria are much more intimately connected both physiologically and structurally.
Both organelles share common fission components to dynamically respond to environmental cues, and the autophagic turnover of both peroxisomes and mitochondria is decisive for cellular homeostasis.
Moreover, peroxisomes can physically associate with mitochondria via specific protein complexes.
Therefore, the structural and functional connection of both organelles is a critical and dynamic feature in the regulation of oxidative metabolism, whose dynamic nature will be revealed in the future.
In this review, we will focus on fundamental aspects of the peroxisome-mitochondria interplay derived from simple models such as yeast and move onto discussing the impact of an impaired peroxisomal and mitochondrial homeostasis on ROS production, aging, and disease in humans.
American Psychological Association (APA)
Pascual-Ahuir, Amparo& Manzanares-Estreder, Sara& Proft, Markus. 2017. Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1196774
Modern Language Association (MLA)
Pascual-Ahuir, Amparo…[et al.]. Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1196774
American Medical Association (AMA)
Pascual-Ahuir, Amparo& Manzanares-Estreder, Sara& Proft, Markus. Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1196774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196774