Emerging Therapeutic Strategies for Limbal Stem Cell Deficiency
Joint Authors
Dong, Ying
Peng, Han
Lavker, Robert M.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Identification and characterization of the limbal epithelial stem cells (LESCs) has proven to be a major accomplishment in anterior ocular surface biology.
These cells have been shown to be a subpopulation of limbal epithelial basal cells, which serve as the progenitor population of the corneal epithelium.
LESCs have been demonstrated to play an important role in maintaining corneal epithelium homeostasis.
Many ocular surface diseases, including intrinsic (e.g., Sjogren’s syndrome) or extrinsic (e.g., alkali or thermal burns) insults, which impair LESCs, can lead to limbal stem cell deficiency (LSCD).
LSCD is characterized by an overgrowth of conjunctival-derived epithelial cells, corneal neovascularization, and chronic inflammation, eventually leading to blindness.
Treatment of LSCD has been challenging, especially in bilateral total LSCD.
Recently, advances in LESC research have led to novel therapeutic approaches for treating LSCD, such as transplantation of the cultured limbal epithelium.
These novel therapeutic approaches have demonstrated efficacy for ocular surface reconstruction and restoration of vision in patients with LSCD.
However, they all have their own limitations.
Here, we describe the current status of LSCD treatment and discuss the advantages and disadvantages of the available therapeutic modalities.
American Psychological Association (APA)
Dong, Ying& Peng, Han& Lavker, Robert M.. 2018. Emerging Therapeutic Strategies for Limbal Stem Cell Deficiency. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1196933
Modern Language Association (MLA)
Dong, Ying…[et al.]. Emerging Therapeutic Strategies for Limbal Stem Cell Deficiency. Journal of Ophthalmology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1196933
American Medical Association (AMA)
Dong, Ying& Peng, Han& Lavker, Robert M.. Emerging Therapeutic Strategies for Limbal Stem Cell Deficiency. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1196933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196933