Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease
Joint Authors
Zhao, Quanzhen
Zheng, Jinhua
Tian, Sijia
Huang, Hongyan
Chen, Yalan
Yang, Xinglong
Xu, Yanming
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-05
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The genetic basis of festination, a common motor symptom in Parkinson’s disease (PD), remains unclear.
Since polymorphism in the alpha-synuclein (SNCA) gene is associated with PD phenotype, we examined whether such polymorphism is also associated with festination.
SNCA polymorphisms rs11931074 and rs894278 were genotyped in a consecutive series of 258 patients with PD, of whom 122 (47.3%) suffered festination.
Univariate analysis revealed significant differences in genotype and minor allele frequencies at rs11931074 or rs894278 between patients with festination and those without it (all p<0.05).
Based on logistic regression, a GG or GT genotype at rs11931074 was associated with higher risk of festination among patients with PD (OR 2.077, 95% CI 1.111–3.883, p=0.022), as was the TT genotype at rs894278 (OR 2.271, 95% CI 1.246–4.139, p=0.007).
Therefore, we conclude that festination is associated with polymorphism at rs11931074 or rs894278 among patients with PD.
American Psychological Association (APA)
Zheng, Jinhua& Yang, Xinglong& Zhao, Quanzhen& Tian, Sijia& Huang, Hongyan& Chen, Yalan…[et al.]. 2017. Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1197020
Modern Language Association (MLA)
Zheng, Jinhua…[et al.]. Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease. Parkinson’s Disease No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1197020
American Medical Association (AMA)
Zheng, Jinhua& Yang, Xinglong& Zhao, Quanzhen& Tian, Sijia& Huang, Hongyan& Chen, Yalan…[et al.]. Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1197020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197020