Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors
Joint Authors
Machado, A. G.
Abboud, Hesham
Thompson, Nicolas R.
Oravivattanakul, Srivadee
Alsallom, Faisal
Reyes, Dennys
Wilson, Kathy
Cerejo, Russell
Yu, Xin Xin
Floden, Darlene
Ahmed, Anwar
Gostkowski, Michal
Ezzeldin, Ayman
Marouf, Hazem
Fernandez, Hubert H.
Genç, Gençer
Mansour, Ossama
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The primary objective was to evaluate predictors of quality of life (QOL) and functional outcomes following deep brain stimulation (DBS) in Parkinson’s disease (PD) patients.
The secondary objective was to identify predictors of global improvement.
Methods.
PD patients who underwent DBS at our Center from 2006 to 2011 were evaluated by chart review and email/phone survey.
Postoperative UPDRS II and EQ-5D were analyzed using simple linear regression adjusting for preoperative score.
For global outcomes, we utilized the Patient Global Impression of Change Scale (PGIS) and the Clinician Global Impression of Change Scale (CGIS).
Results.
There were 130 patients in the dataset.
Preoperative and postoperative UPDRS II and EQ-5D were available for 45 patients, PGIS for 67 patients, and CGIS for 116 patients.
Patients with falls/postural instability had 6-month functional scores and 1-year QOL scores that were significantly worse than patients without falls/postural instability.
For every 1-point increase in preoperative UPDRS III and for every 1-unit increase in body mass index (BMI), the 6-month functional scores significantly worsened.
Patients with tremors, without dyskinesia, and without gait-freezing were more likely to have “much” or “very much” improved CGIS.
Conclusions.
Presence of postural instability, high BMI, and worse baseline motor scores were the greatest predictors of poorer functional and QOL outcomes after DBS.
American Psychological Association (APA)
Abboud, Hesham& Genç, Gençer& Thompson, Nicolas R.& Oravivattanakul, Srivadee& Alsallom, Faisal& Reyes, Dennys…[et al.]. 2017. Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197071
Modern Language Association (MLA)
Abboud, Hesham…[et al.]. Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors. Parkinson’s Disease No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1197071
American Medical Association (AMA)
Abboud, Hesham& Genç, Gençer& Thompson, Nicolas R.& Oravivattanakul, Srivadee& Alsallom, Faisal& Reyes, Dennys…[et al.]. Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson’s Disease Patients: Disease, Patient, and Surgical Factors. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197071