Effect of Altered Retinal ConesOpsins on Refractive Development under Monochromatic Lights in Guinea Pigs
Joint Authors
Liu, Hong
Dai, Jinhui
Yu, Manrong
Zou, Leilei
Zhu, Xiaoyu
Liu, Rui
Ma, Fei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To analyze the changes of refraction and metabolism of the retinal cones under monochromatic lights in guinea pigs.
Methods.
Sixty guinea pigs were randomly divided into a short-wavelength light (SL) group, a middle-wavelength light (ML) group, and a white light (WL) group.
Refraction and axial length were measured before and after 10-week illumination.
The densities of S-cones and M-cones were determined by retinal cone immunocytochemistry, and the expressions of S-opsins and M-opsins were determined by real-time PCR and Western blot.
Results.
After 10-week illumination, the guinea pigs developed relative hyperopia in the SL group and relative myopia in the ML group.
Compared with the WL group, the density of S-cones and S-opsins increased while M-cones and M-opsins decreased in the SL group (all, p<0.05); conversely, the density of S-cones and S-opsins decreased while M-cones and M-opsins increased in the ML group (all, p<0.05).
Increased S-cones/opsins and decreased M-cones/opsins were induced by short-wavelength lights.
Decreased S-cones/opsins and increased M-cones/opsins were induced by middle-wavelength lights.
Conclusions.
Altered retinal cones/opsins induced by monochromatic lights might be involved in the refractive development in guinea pigs.
American Psychological Association (APA)
Zou, Leilei& Zhu, Xiaoyu& Liu, Rui& Ma, Fei& Yu, Manrong& Liu, Hong…[et al.]. 2018. Effect of Altered Retinal ConesOpsins on Refractive Development under Monochromatic Lights in Guinea Pigs. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1197111
Modern Language Association (MLA)
Zou, Leilei…[et al.]. Effect of Altered Retinal ConesOpsins on Refractive Development under Monochromatic Lights in Guinea Pigs. Journal of Ophthalmology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1197111
American Medical Association (AMA)
Zou, Leilei& Zhu, Xiaoyu& Liu, Rui& Ma, Fei& Yu, Manrong& Liu, Hong…[et al.]. Effect of Altered Retinal ConesOpsins on Refractive Development under Monochromatic Lights in Guinea Pigs. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1197111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197111