The Single Nucleotide Polymorphism rs1014290 of the SLC2A9 Gene Is Associated with Uric Acid Metabolism in Parkinson’s Disease
Joint Authors
Luo, Wei-Feng
Liu, Chunfeng
Miao, Jiangfang
Liu, Jing
Xiao, Li
Zheng, Jiedi
Zhu, Zufu
Li, Kai
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Individuals with Parkinson’s disease (PD) have lower uric acid levels than those without PD, and the CC genotype and C minor allele of a single nucleotide polymorphism (SNP), rs1014290 of SLC2A9, are associated with lower uric acid levels.
We investigated the association of rs1014290 with uric acid metabolism in a cohort of PD cases (220) and controls (110) in a Han Chinese population.
Uric acid levels were determined and rs1014290 was assayed using a mutation-sensitive on/off switch technology.
PD uric acid levels (291.65 ± 76.29 μmol/L) were significantly lower than the controls (325.73 ± 74.23 μmol/L, P<0.001, t-test).
Individuals with rs1014290 TT and CT genotypes had higher uric acid levels, and those with the CC genotype had the lowest uric acid levels among both control and PD cases.
The CC genotype and the C minor allele were statistically more frequent in the PD group compared to the control group.
Those with the CC genotype had a statistically significant higher risk of PD than those with the TT or TC genotype (odds ratio [OR] = 2.249, 95% confidence interval [CI]: 1.129–4.480, and P=0.021).
Thus, SLC2A9 rs1014290 is related to lower uric acid levels in PD patients and can be a risk factor for PD in the Han population.
American Psychological Association (APA)
Miao, Jiangfang& Liu, Jing& Xiao, Li& Zheng, Jiedi& Liu, Chunfeng& Zhu, Zufu…[et al.]. 2017. The Single Nucleotide Polymorphism rs1014290 of the SLC2A9 Gene Is Associated with Uric Acid Metabolism in Parkinson’s Disease. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197112
Modern Language Association (MLA)
Miao, Jiangfang…[et al.]. The Single Nucleotide Polymorphism rs1014290 of the SLC2A9 Gene Is Associated with Uric Acid Metabolism in Parkinson’s Disease. Parkinson’s Disease No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1197112
American Medical Association (AMA)
Miao, Jiangfang& Liu, Jing& Xiao, Li& Zheng, Jiedi& Liu, Chunfeng& Zhu, Zufu…[et al.]. The Single Nucleotide Polymorphism rs1014290 of the SLC2A9 Gene Is Associated with Uric Acid Metabolism in Parkinson’s Disease. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197112