Evolution of Orofacial Symptoms and Disease Progression in Idiopathic Parkinson’s Disease: Longitudinal Data from the Jönköping Parkinson Registry
Joint Authors
Skogar, Örjan
Lökk, Johan
Fereshtehnejad, Seyed-Mohammad
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Orofacial symptoms are common in Parkinson’s disease (PD) both as initial manifestations and late markers of disease complications.
We aimed to investigate the evolution of orofacial manifestations and their prognostic value throughout PD progression.
Methods.
Data was obtained from “Jönköping Parkinson Registry” database on routine care visits of 314 people with idiopathic PD in southern Sweden.
Information on baseline symptomatology, orofacial features, UPDRS, and medications was recorded at baseline and during each follow-up visit within an average of 4.2 (range: 1–12) years.
Results.
Hypomimia, affected speech, drooling, and impaired swallowing were present in 37.3%/91.6%, 14.1%/65.5%, 11.7%/55.3%, and 10.2%/34.5% at baseline/follow-up, respectively.
Male sex [OR = 2.4 (95% CI: 1.0–5.9)], UPDRS motor scores [OR = 1.2 (95% CI: 1.1–1.3)], dominant rigidity [OR = 5.2 (95% CI: 1.4–19.1)], and autonomic disturbance [OR = 3.4 (95% CI: 1.1–10.9)] were risk factors for drooling.
Individuals with more severe orofacial burden at baseline had shorter median time to develop UPDRS-Part III > 28 [3rd tertile = 4.7 yr, 2nd tertile = 6.2 yr, and 1st tertile = 7.8 yr; p = 0.014].
Conclusions.
Majority of people with PD manifest orofacial manifestations at either early or late stages of the disease.
PD severity, symmetry of motor disturbances, and autonomic disorders correlate with orofacial symptoms.
Individuals with more severe orofacial burden at baseline progressed faster to more advanced stages.
American Psychological Association (APA)
Fereshtehnejad, Seyed-Mohammad& Skogar, Örjan& Lökk, Johan. 2017. Evolution of Orofacial Symptoms and Disease Progression in Idiopathic Parkinson’s Disease: Longitudinal Data from the Jönköping Parkinson Registry. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197130
Modern Language Association (MLA)
Fereshtehnejad, Seyed-Mohammad…[et al.]. Evolution of Orofacial Symptoms and Disease Progression in Idiopathic Parkinson’s Disease: Longitudinal Data from the Jönköping Parkinson Registry. Parkinson’s Disease No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1197130
American Medical Association (AMA)
Fereshtehnejad, Seyed-Mohammad& Skogar, Örjan& Lökk, Johan. Evolution of Orofacial Symptoms and Disease Progression in Idiopathic Parkinson’s Disease: Longitudinal Data from the Jönköping Parkinson Registry. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197130