Twice-Daily versus Once-Daily Pramipexole Extended Release Dosage Regimens in Parkinson’s Disease

Joint Authors

Jeon, Beom S.
Yun, Ji Young
Kim, Young Eun
Yang, Hui-Jun
Kim, Han-Joon

Source

Parkinson’s Disease

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-02-07

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases
Medicine

Abstract EN

This open-label study aimed to compare once-daily and twice-daily pramipexole extended release (PER) treatment in Parkinson’s disease (PD).

PD patients on dopamine agonist therapy, but with unsatisfactory control, were enrolled.

Existing agonist doses were switched into equivalent PER doses.

Subjects were consecutively enrolled into either once-daily-first or twice-daily-first groups and received the prescribed amount in one or two, respectively, daily doses for 8 weeks.

For the second period, subjects switched regimens in a crossover manner.

The forty-four patients completed a questionnaire requesting preference during their last visit.

We measured the UPDRS-III, Hoehn and Yahr stages (H&Y) in medication-on state, Parkinson’s disease sleep scale (PDSS), and Epworth Sleepiness Scale.

Eighteen patients preferred a twice-daily regimen, 12 preferred a once-daily regimen, and 14 had no preference.

After the trial, 14 subjects wanted to be on a once-daily regimen, 25 chose a twice-daily regimen, and 5 wanted to maintain the prestudy regimen.

Main reasons for choosing the twice-daily regimen were decreased off-duration, more tolerable off-symptoms, and psychological stability.

The mean UPDRS-III, H&Y, and PDSS were not different.

Daytime sleepiness was significantly high in the once-daily regimen, whereas nocturnal hallucinations were more common in the twice-daily.

Multiple dosing should be considered if once-daily dosing is unsatisfactory.

This study is registered as NCT01515774 at ClinicalTrials.gov.

American Psychological Association (APA)

Yun, Ji Young& Kim, Young Eun& Yang, Hui-Jun& Kim, Han-Joon& Jeon, Beom S.. 2017. Twice-Daily versus Once-Daily Pramipexole Extended Release Dosage Regimens in Parkinson’s Disease. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197141

Modern Language Association (MLA)

Yun, Ji Young…[et al.]. Twice-Daily versus Once-Daily Pramipexole Extended Release Dosage Regimens in Parkinson’s Disease. Parkinson’s Disease No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1197141

American Medical Association (AMA)

Yun, Ji Young& Kim, Young Eun& Yang, Hui-Jun& Kim, Han-Joon& Jeon, Beom S.. Twice-Daily versus Once-Daily Pramipexole Extended Release Dosage Regimens in Parkinson’s Disease. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197141

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1197141