Impact of Unilateral Orbital Radiotherapy on the Structure and Function of Bilateral Human Meibomian Gland
Joint Authors
Zhang, Fuquan
Li, Ying
Chen, Di
Liu, Xiaowei
Guan, Hui
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Radiotherapy (RT) has widely been used to treat ocular tumors, yet the impact of orbital radiation to the meibomian gland has rarely been studied.
Our study aims at evaluating the bilateral meibomian gland structure and function 12 months after unilateral orbital RT in patients with ocular tumors.
Methods.
An observational case-control study.
A total of 10 eyes 12 months after unilateral orbital RT, 10 contralateral eyes, and 10 normal controls were enrolled.
Meibomian gland loss (MGL), lipid layer thickness (LLT), tear film breakup time (TBUT), Schirmer I test, and cornea fluorescein staining were measured.
Ocular Surface Disease Index (OSDI) of the RT patients was assessed and compared with normal controls.
Results.
The cumulative median radiotherapy dosage for the patients was 45 (range: 30, 70) Gy.
The OSDI score of the patients was significantly greater than the normal controls (22.92 (range: 10.42, 37.50) vs 6.25 (range: 2.08, 10.42), p≤0.001).
Significant differences of upper MGL, lower MGL, LLT, and TBUT were found between the diseased eyes and normal controls (37.79% (range: 12.87, 92.41) vs 12.63% (range: 6.13, 42.34), p=0.007; 61.31% (range: 44.67, 87.98) vs 15.53% (range: 7.65, 45.13), p≤0.001; 40 ICU (range: 23, 100) vs 81.5 ICU (range: 54, 100), p=0.007; 3.5 s (range: 2, 8) vs 6.5 s (range: 5, 10), p=0.002).
The upper MGL and TBUT of the contralateral eyes were also considerably damaged compared with normal controls.
Lower eyelid MGL and cornea staining score of the diseased eye were significantly correlated with radiation dosage (r = 0.913 and 0.680; p=0.001 and 0.044, respectively).
Conclusion.
Orbital radiotherapy could cause significant damage to the meibomian gland structure and function, not only the diseased eyes but also the contralateral eyes.
American Psychological Association (APA)
Chen, Di& Liu, Xiaowei& Li, Ying& Guan, Hui& Zhang, Fuquan. 2018. Impact of Unilateral Orbital Radiotherapy on the Structure and Function of Bilateral Human Meibomian Gland. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1197179
Modern Language Association (MLA)
Chen, Di…[et al.]. Impact of Unilateral Orbital Radiotherapy on the Structure and Function of Bilateral Human Meibomian Gland. Journal of Ophthalmology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1197179
American Medical Association (AMA)
Chen, Di& Liu, Xiaowei& Li, Ying& Guan, Hui& Zhang, Fuquan. Impact of Unilateral Orbital Radiotherapy on the Structure and Function of Bilateral Human Meibomian Gland. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1197179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197179