Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice
Joint Authors
Seo, Hong Seog
Han, Yoon-Mi
Lee, Yong-Jik
Jang, Yoo-Na
Kim, Hyun-Min
Jin, Changbae
Kim, Hyoung Ja
Jeong, Jong-Min
Son, Min Jeoung
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-23
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Aster glehni is well known for its therapeutic properties.
This study was performed to investigate the effects of A.
glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue.
Body and abdominal adipose tissue weights and serum triglyceride level decreased in all groups treated with A.
glehni.
Serum adiponectin concentration and protein levels of peroxisome proliferator-activated receptor δ, 5′ adenosine monophosphate-activated protein kinase, acetyl-CoA carboxylase, superoxide dismutase, and PPARγ coactivator 1-alpha in liver tissues increased in the groups treated with A.
glehni.
Conversely, protein levels of ATP citrate lyase, fatty acid synthase, tumor necrosis factor α, and 3-hydroxy-3-methylglutaryl-CoA reductase and the concentrations of interleukin 6 and reactive oxygen species decreased upon A.
glehni.
Triglyceride concentration in the liver was lower in mice treated with A.
glehni than in control mice.
Lipid accumulation in HepG2 and 3T3-L1 cells decreased upon A.
glehni treatment; this effect was suppressed in the presence of the PPARδ antagonist, GSK0660.
Our findings suggest that A.
glehni extracts may ameliorate NAFLD through regulation of PPARδ, adiponectin, and the related subgenes.
American Psychological Association (APA)
Lee, Yong-Jik& Jang, Yoo-Na& Han, Yoon-Mi& Kim, Hyun-Min& Jeong, Jong-Min& Son, Min Jeoung…[et al.]. 2017. Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice. PPAR Research،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1197219
Modern Language Association (MLA)
Lee, Yong-Jik…[et al.]. Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice. PPAR Research No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1197219
American Medical Association (AMA)
Lee, Yong-Jik& Jang, Yoo-Na& Han, Yoon-Mi& Kim, Hyun-Min& Jeong, Jong-Min& Son, Min Jeoung…[et al.]. Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1197219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197219