Bezafibrate Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis
Joint Authors
Tang, Qi-Zhu
Wei, Wen-Ying
Ma, Zhen-Guo
Xu, Si-Chi
Yuan, Yu-Pei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Peroxisome proliferator-activated receptor-α (PPAR-α) is closely associated with the development of cardiac hypertrophy.
Previous studies have indicated that bezafibrate (BZA), a PPAR-α agonist, could attenuate insulin resistance and obesity.
This study was designed to determine whether BZA could protect against pressure overload-induced cardiac hypertrophy.
Methods.
Mice were orally given BZA (100 mg/kg) for 7 weeks beginning 1 week after aortic banding (AB) surgery.
Cardiac hypertrophy was assessed based on echocardiographic, histological, and molecular aspects.
Moreover, neonatal rat ventricular cardiomyocytes (NRVMs) were used to investigate the effects of BZA on the cardiomyocyte hypertrophic response in vitro.
Results.
Our study demonstrated that BZA could alleviate cardiac hypertrophy and fibrosis in mice subjected to AB surgery.
BZA treatment also reduced the phosphorylation of protein kinase B (AKT)/glycogen synthase kinase-3β (GSK3β) and mitogen-activated protein kinases (MAPKs).
BZA suppressed phenylephrine- (PE-) induced hypertrophy of cardiomyocyte in vitro.
The protective effects of BZA were abolished by the treatment of the PPAR-α antagonist in vitro.
Conclusions.
BZA could attenuate pressure overload-induced cardiac hypertrophy and fibrosis.
American Psychological Association (APA)
Xu, Si-Chi& Ma, Zhen-Guo& Wei, Wen-Ying& Yuan, Yu-Pei& Tang, Qi-Zhu. 2017. Bezafibrate Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis. PPAR Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197245
Modern Language Association (MLA)
Xu, Si-Chi…[et al.]. Bezafibrate Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis. PPAR Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1197245
American Medical Association (AMA)
Xu, Si-Chi& Ma, Zhen-Guo& Wei, Wen-Ying& Yuan, Yu-Pei& Tang, Qi-Zhu. Bezafibrate Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197245