Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease
Joint Authors
Lu, Jie
Kong, Rui
Wang, Nan
Luo, Hui
Xu, Xiaorong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming a major cause of chronic liver disease worldwide.
Concurrent to an increase in NAFLD prevalence, there is an increase in the obesity epidemic and the correlated insulin-resistant state.
It is a challenge to diagnose NAFLD because many patients are asymptomatic until the later stages of disease.
The most common symptoms include fatigue, malaise, and discomfort in the right upper quadrant.
The major and most accurate tool to clinically diagnose NAFLD is a liver biopsy, followed by histological analysis.
However, this procedure is invasive and often carries a high risk of complications.
Currently, there are no officially approved medications for the treatment of NAFLD.
Although lifestyle modifications with proper diet and exercise have been shown to be beneficial, this has been difficult to achieve and sustain for many patients.
Effective pharmacological treatments are still lacking; therefore, additional research to identify novel drugs is clearly warranted.
PPARs are promising drug targets for the management of NAFLD and its related conditions of type 2 diabetes mellitus and cardiovascular disease.
In this review, we provide an overview of recent studies on the association of PPARs and NAFLD.
American Psychological Association (APA)
Wang, Nan& Kong, Rui& Luo, Hui& Xu, Xiaorong& Lu, Jie. 2017. Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease. PPAR Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197270
Modern Language Association (MLA)
Wang, Nan…[et al.]. Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease. PPAR Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1197270
American Medical Association (AMA)
Wang, Nan& Kong, Rui& Luo, Hui& Xu, Xiaorong& Lu, Jie. Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197270