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MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers
Joint Authors
Foti, Michelangelo
Portius, Dorothea
Sobolewski, Cyril
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-12
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-dependent nuclear receptors, which control the transcription of genes involved in energy homeostasis and inflammation and cell proliferation/differentiation.
Alterations of PPARs’ expression and/or activity are commonly associated with metabolic disorders occurring with obesity, type 2 diabetes, and fatty liver disease, as well as with inflammation and cancer.
Emerging evidence now indicates that microRNAs (miRNAs), a family of small noncoding RNAs, which fine-tune gene expression, play a significant role in the pathophysiological mechanisms regulating the expression and activity of PPARs.
Herein, the regulation of PPARs by miRNAs is reviewed in the context of metabolic disorders, inflammation, and cancer.
The reciprocal control of miRNAs expression by PPARs, as well as the therapeutic potential of modulating PPAR expression/activity by pharmacological compounds targeting miRNA, is also discussed.
American Psychological Association (APA)
Portius, Dorothea& Sobolewski, Cyril& Foti, Michelangelo. 2017. MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers. PPAR Research،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1197272
Modern Language Association (MLA)
Portius, Dorothea…[et al.]. MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers. PPAR Research No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1197272
American Medical Association (AMA)
Portius, Dorothea& Sobolewski, Cyril& Foti, Michelangelo. MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1197272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197272