Fluid Retention Caused by Rosiglitazone Is Related to Increases in AQP2 and αENaC Membrane Expression
Joint Authors
Xu, Jinghua
Pan, Mingyue
Wang, Xiaoli
Xu, Lishi
Li, Lanfang
Xu, Cheng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Peroxisome proliferator activated receptor-γ (PPARγ) is a ligand-activated transcription factor of the nuclear hormone receptor superfamily.
The decreased phosphorylation of PPARγ due to rosiglitazone (ROS) is the main reason for the increased insulin sensitivity caused by this antidiabetic drug.
However, there is no clear evidence whether the nuclear translocation of p-PPARγ stimulated by ROS is related to fluid retention.
It is also unclear whether the translocation of p-PPARγ is associated with the change of aquaporin-2 (AQP2) and epithelial sodium channel α subunit (αENaC) in membranes, cytoplasm, and nucleus.
Our experiments indicate that ROS significantly downregulates nuclear p-PPARγ and increases membrane AQP2 and αENaC; however, SR1664 (a nonagonist PPARγ ligand) reduces p-PPARγ and has no effect on AQP2 and αENaC.
Therefore, we conclude that in vitro the fluid retention caused by ROS is associated with the increases in membrane αENaC and AQP2 but has little relevance to the phosphorylation of PPARγ.
American Psychological Association (APA)
Xu, Jinghua& Pan, Mingyue& Wang, Xiaoli& Xu, Lishi& Li, Lanfang& Xu, Cheng. 2017. Fluid Retention Caused by Rosiglitazone Is Related to Increases in AQP2 and αENaC Membrane Expression. PPAR Research،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1197287
Modern Language Association (MLA)
Xu, Jinghua…[et al.]. Fluid Retention Caused by Rosiglitazone Is Related to Increases in AQP2 and αENaC Membrane Expression. PPAR Research No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1197287
American Medical Association (AMA)
Xu, Jinghua& Pan, Mingyue& Wang, Xiaoli& Xu, Lishi& Li, Lanfang& Xu, Cheng. Fluid Retention Caused by Rosiglitazone Is Related to Increases in AQP2 and αENaC Membrane Expression. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1197287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197287