Crosstalk between the Androgen Receptor and PPAR Gamma Signaling Pathways in the Prostate
Joint Authors
Stewart, LaMonica V.
Olokpa, Emuejevoke
Moss, Patrice E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Nuclear receptors are a superfamily of ligand-activated transcription factors that play critical roles in the regulation of normal biological processes and several disease states.
Of the nuclear receptors expressed within the prostate, the androgen receptor (AR) promotes the differentiation of prostatic epithelial cells and stimulates production of enzymes needed for liquefaction of semen.
Multiple forms of AR also promote the growth of both early and late stage prostate cancers.
As a result, drugs that target the AR signaling pathway are routinely used to treat patients with advanced forms of prostate cancer.
Data also suggest that a second member of the nuclear receptor superfamily, the peroxisome proliferator activated receptor gamma (PPARγ), is a tumor suppressor that regulates growth of normal prostate and prostate cancers.
Recent studies indicate there is a bidirectional interaction between AR and PPARγ, with each receptor influencing the expression and/or activity of the other within prostatic tissues.
In this review, we examine how AR and PPARγ each regulate the growth and development of normal prostatic epithelial cells and prostate cancers.
We also discuss interactions between the AR and PPARγ signaling pathways and how those interactions may influence prostate biology.
American Psychological Association (APA)
Olokpa, Emuejevoke& Moss, Patrice E.& Stewart, LaMonica V.. 2017. Crosstalk between the Androgen Receptor and PPAR Gamma Signaling Pathways in the Prostate. PPAR Research،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1197303
Modern Language Association (MLA)
Olokpa, Emuejevoke…[et al.]. Crosstalk between the Androgen Receptor and PPAR Gamma Signaling Pathways in the Prostate. PPAR Research No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1197303
American Medical Association (AMA)
Olokpa, Emuejevoke& Moss, Patrice E.& Stewart, LaMonica V.. Crosstalk between the Androgen Receptor and PPAR Gamma Signaling Pathways in the Prostate. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1197303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197303