Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes

Joint Authors

Fisher-Hoch, Susan P.
McCormick, Joseph B.
Rianon, Nahid J.
Smith, Scott M.
Lee, MinJae
Pervin, Hannah
Musgrave, Paul
Watt, Gordon P.
Nader, Shahla
Ambrose, Catherine G.
Khosla, Sundeep

Source

Journal of Osteoporosis

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-05-13

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases
Medicine

Abstract EN

Altered bone quality, caused by underlying metabolic changes of type 2 diabetes (T2D), has been hypothesized to cause altered bone strength and turnover leading to increased fracture risk in T2D patients.

Current understanding about changes in bone turnover markers in T2D patients is mainly based on studies focused on Caucasian men and women.

However, Hispanic populations have the highest prevalence of both T2D and osteoporosis in the US.

We investigated associations of glycemic control (in terms of glycated hemoglobin [HbA1c]) and bone turnover rate in 69 older (≥50 years) Mexican American Cameron County Hispanic Cohort (CCHC) participants with T2D.

Multivariable analyses were conducted to assess the associations between HbA1c (%), serum osteocalcin (OC), and serum sclerostin.

In agreement with published reports from other racial/ethnic populations, our study found that lower bone turnover (indicated by lower serum OC) occurred in Mexican American men with T2D who had poorer glycemic control.

For the women in our study, we found no significant association between glycemic control and OC.

In contrast, HbA1c was positively associated with sclerostin for women, with near significance (p=0.07), while no association was found in men.

We recommend screening Mexican American individuals with T2D, specifically those with poor glycemic control, for bone loss and fracture risk.

American Psychological Association (APA)

Rianon, Nahid J.& Smith, Scott M.& Lee, MinJae& Pervin, Hannah& Musgrave, Paul& Watt, Gordon P.…[et al.]. 2018. Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes. Journal of Osteoporosis،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1197307

Modern Language Association (MLA)

Rianon, Nahid J.…[et al.]. Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes. Journal of Osteoporosis No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1197307

American Medical Association (AMA)

Rianon, Nahid J.& Smith, Scott M.& Lee, MinJae& Pervin, Hannah& Musgrave, Paul& Watt, Gordon P.…[et al.]. Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes. Journal of Osteoporosis. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1197307

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1197307