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Efficacy and Safety of Transdermal Buprenorphine versus Oral TramadolAcetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery
Joint Authors
Lee, Jae Hyup
Kim, Jin-Hyok
Kim, Jin-Hwan
Kim, Hak-Sun
Min, Woo-Kie
Park, Ye-Soo
Lee, Kyu-Yeol
Lee, Jung-Hee
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
Control of persistent pain following spinal surgery is an unmet clinical need.
This study compared the efficacy and safety of buprenorphine transdermal system (BTDS) to oral tramadol/acetaminophen (TA) in Korean patients with persistent, moderate pain following spinal surgery.
Methods.
Open-label, interventional, randomized multicenter study.
Adults with persistent postoperative pain (Numeric Rating Scale [NRS] ≥ 4 at 14–90 days postsurgery) were enrolled.
Patients received once-weekly BTDS (n=47; 5 μg/h titrated to 20 μg/h) or twice-daily TA (n=40; tramadol 37.5 mg/acetaminophen 325 mg, one tablet titrated to 4 tablets) for 6 weeks.
The study compared pain reduction with BTDS versus TA at week 6.
Quality of life (QoL), treatment satisfaction, medication compliance, and adverse events (AEs) were assessed.
Findings.
At week 6, both groups reported significant pain reduction (mean NRS change: BTDS −2.02; TA −2.76, both P<0.0001) and improved QoL (mean EQ-5D index change: BTDS 0.10; TA 0.19, both P<0.05).
The BTDS group achieved better medication compliance (97.8% versus 91.0%).
Incidence of AEs (26.1% versus 20.0%) and adverse drug reactions (20.3% versus 16.9%) were comparable between groups.
Implications.
For patients with persistent pain following spinal surgery, BTDS is an alternative to TA for reducing pain and supports medication compliance.
This trial is registered with Clinicaltrials.gov: NCT01983111.
American Psychological Association (APA)
Lee, Jae Hyup& Kim, Jin-Hyok& Kim, Jin-Hwan& Kim, Hak-Sun& Min, Woo-Kie& Park, Ye-Soo…[et al.]. 2017. Efficacy and Safety of Transdermal Buprenorphine versus Oral TramadolAcetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery. Pain Research and Management،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1197343
Modern Language Association (MLA)
Lee, Jae Hyup…[et al.]. Efficacy and Safety of Transdermal Buprenorphine versus Oral TramadolAcetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery. Pain Research and Management No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1197343
American Medical Association (AMA)
Lee, Jae Hyup& Kim, Jin-Hyok& Kim, Jin-Hwan& Kim, Hak-Sun& Min, Woo-Kie& Park, Ye-Soo…[et al.]. Efficacy and Safety of Transdermal Buprenorphine versus Oral TramadolAcetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1197343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197343