Gestational Outcomes of Pregnant Women Who Have Had Invasive Prenatal Testing for the Prenatal Diagnosis of Duchenne Muscular Dystrophy
Joint Authors
Beksac, Mehmet Sinan
Tanacan, Atakan
Orgul, Gokcen
Aydin Hakli, Duygu
Soyak, Burcu
Balci Hayta, Burcu
Dincer, Pervin
Topaloglu, Haluk
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
To show the importance of prenatal diagnosis of Duchenne Muscular Dystrophy (DMD) and to demonstrate the effect of DMD gene mutations on gestational outcomes.
Materials and Methods.
We retrospectively evaluated 89 pregnancies in 81 individuals who were referred to Hacettepe University for prenatal diagnosis of DMD between January 2000 and December 2015.
Prenatal diagnostic methods (chorionic villus sampling (CVS): 66, amniocentesis (AC): 23) were compared for test results, demographic features, and obstetric outcomes of pregnancies.
The female fetuses were divided into two groups according to the DMD status (healthy or carrier) to understand the effect of DMD gene mutations on obstetric outcomes.
Results.
Eight prenatally diagnosed disease-positive fetuses were terminated.
There was no statistically significant difference between the CVS and AC groups in terms of study variables.
There were 46 male fetuses (51.6%) and 43 female fetuses (48.4%).
Fifteen of the female fetuses were carriers (34.8%).
Median birthweight values were statistically insignificantly lower in the carrier group.
Conclusion.
Pregnancies at risk for DMD should be prenatally tested to prevent the effect of disease on families and DMD carrier fetuses had obstetric outcomes similar to DMD negative female fetuses.
American Psychological Association (APA)
Beksac, Mehmet Sinan& Tanacan, Atakan& Aydin Hakli, Duygu& Orgul, Gokcen& Soyak, Burcu& Balci Hayta, Burcu…[et al.]. 2018. Gestational Outcomes of Pregnant Women Who Have Had Invasive Prenatal Testing for the Prenatal Diagnosis of Duchenne Muscular Dystrophy. Journal of Pregnancy،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1197422
Modern Language Association (MLA)
Beksac, Mehmet Sinan…[et al.]. Gestational Outcomes of Pregnant Women Who Have Had Invasive Prenatal Testing for the Prenatal Diagnosis of Duchenne Muscular Dystrophy. Journal of Pregnancy No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1197422
American Medical Association (AMA)
Beksac, Mehmet Sinan& Tanacan, Atakan& Aydin Hakli, Duygu& Orgul, Gokcen& Soyak, Burcu& Balci Hayta, Burcu…[et al.]. Gestational Outcomes of Pregnant Women Who Have Had Invasive Prenatal Testing for the Prenatal Diagnosis of Duchenne Muscular Dystrophy. Journal of Pregnancy. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1197422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197422