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OmpA-Like Proteins of Porphyromonas gingivalis Mediate Resistance to the Antimicrobial Peptide LL-37
Joint Authors
Horie, Toshi
Inomata, Megumi
Into, Takeshi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Subgingival bacteria are continually exposed to gingival crevicular fluids that are derived from serum, which contain various bactericidal agents.
The periodontopathic bacterium Porphyromonas gingivalis has been demonstrated to possess a variety of abilities to resist bactericidal agents, due to which it is able to propagate in the subgingival environment.
We previously demonstrated that the major surface glycoproteins of P.
gingivalis—Pgm6 and Pgm7, also called outer membrane protein A-like proteins (OmpALPs)—mediate resistance to the bactericidal activity of human serum, but their precise role remains unknown.
In this study, we investigated the sensitivity of the wild-type and Pgm6/Pgm7-deficient P.
gingivalis strains toward major antimicrobial peptides in the oral cavity, human β-defensins (hBDs) 1-3, and human cathelicidin LL-37.
hBDs showed a considerably weak bactericidal activity against both bacterial strains.
LL-37 also showed a weak activity against the wild-type strain; however, it showed a significant activity against the Pgm6/Pgm7-deficient strain.
In the Pgm6/Pgm7-deficient strain, LL-37 remarkably accumulated on the bacterial cell surface, which may result in the destruction of the outer membrane.
Additionally, the bactericidal activity of hBDs against the Pgm6/Pgm7-deficient strain was found to be synergistically promoted in the presence of LL-37.
Our results suggest that OmpALPs specifically protect P.
gingivalis from the bactericidal activity of LL-37; thus, P.
gingivalis may adeptly survive in LL-37-producing subgingival environments.
American Psychological Association (APA)
Horie, Toshi& Inomata, Megumi& Into, Takeshi. 2018. OmpA-Like Proteins of Porphyromonas gingivalis Mediate Resistance to the Antimicrobial Peptide LL-37. Journal of Pathogens،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1197472
Modern Language Association (MLA)
Horie, Toshi…[et al.]. OmpA-Like Proteins of Porphyromonas gingivalis Mediate Resistance to the Antimicrobial Peptide LL-37. Journal of Pathogens No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1197472
American Medical Association (AMA)
Horie, Toshi& Inomata, Megumi& Into, Takeshi. OmpA-Like Proteins of Porphyromonas gingivalis Mediate Resistance to the Antimicrobial Peptide LL-37. Journal of Pathogens. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1197472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197472