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Effects of Glutathione on Mechanical Allodynia and Central Sensitization in Chronic Postischemic Pain Rats
Joint Authors
Yeo, Jinseok
Jung, Hoon
Lee, Hyerim
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The chronic postischemia pain (CPIP) model is an animal model using ischemia/reperfusion injury that mimics the symptoms of complex regional pain syndrome type I.
Glutathione (GSH) prevents ischemia/reperfusion injury by scavenging free radicals.
We conducted this study to investigate the protective effect of GSH in CPIP rats via changes of mechanical allodynia and phospholyration of the N-methyl-D-aspartate receptor subunit GluN1.
Methods.
We divided 45 rats into 5 groups: sham, CPIP, CPIP + GSH 100 mg/kg, CPIP + GSH 200 mg/kg, and CPIP + GSH 500 mg/kg.
Rats in the sham and CPIP groups received normal saline and rats in the other groups received GSH at the designated doses thirty minutes prior to reperfusion.
Withdrawal thresholds were evaluated before sugery as well as 1, 3, and 7 days after surgery.
pGluN1 level in the spinal cord was also measured.
Results.
GSH treated rats show a significant increase in the withdrawal thresholds of both hind paws as compared with the CPIP group dose-dependently.
The expression of pGluN1 in the GSH treated rats significantly decreased as compared to the CPIP group (all P < 0.05).
Conclusion.
These findings suggest that GSH inhibited the development of mechanical allodynia and central sensitization in CPIP rats.
American Psychological Association (APA)
Yeo, Jinseok& Jung, Hoon& Lee, Hyerim. 2017. Effects of Glutathione on Mechanical Allodynia and Central Sensitization in Chronic Postischemic Pain Rats. Pain Research and Management،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1197477
Modern Language Association (MLA)
Yeo, Jinseok…[et al.]. Effects of Glutathione on Mechanical Allodynia and Central Sensitization in Chronic Postischemic Pain Rats. Pain Research and Management No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1197477
American Medical Association (AMA)
Yeo, Jinseok& Jung, Hoon& Lee, Hyerim. Effects of Glutathione on Mechanical Allodynia and Central Sensitization in Chronic Postischemic Pain Rats. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1197477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197477