Amygdala Plasticity and Pain
Joint Authors
Thompson, Jeremy M.
Neugebauer, Volker
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The amygdala is a limbic brain region that plays a key role in emotional processing, neuropsychiatric disorders, and the emotional-affective dimension of pain.
Preclinical and clinical studies have identified amygdala hyperactivity as well as impairment of cortical control mechanisms in pain states.
Hyperactivity of basolateral amygdala (BLA) neurons generates enhanced feedforward inhibition and deactivation of the medial prefrontal cortex (mPFC), resulting in pain-related cognitive deficits.
The mPFC sends excitatory projections to GABAergic neurons in the intercalated cell mass (ITC) in the amygdala, which project to the laterocapsular division of the central nucleus of the amygdala (CeLC; output nucleus) and serve gating functions for amygdala output.
Impairment of these cortical control mechanisms allows the development of amygdala pain plasticity.
Mechanisms of abnormal amygdala activity in pain with particular focus on loss of cortical control mechanisms as well as new strategies to correct pain-related amygdala dysfunction will be discussed in the present review.
American Psychological Association (APA)
Thompson, Jeremy M.& Neugebauer, Volker. 2017. Amygdala Plasticity and Pain. Pain Research and Management،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197519
Modern Language Association (MLA)
Thompson, Jeremy M.& Neugebauer, Volker. Amygdala Plasticity and Pain. Pain Research and Management No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1197519
American Medical Association (AMA)
Thompson, Jeremy M.& Neugebauer, Volker. Amygdala Plasticity and Pain. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197519