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Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model
Joint Authors
Jeong, Wook
Kung, Hsichiang
Cheng, Chia Chi
Lim, Changwoo
Jung, Min Jung
Lee, Jaeho
Kim, Doo Sik
Shin, Yusom
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Several studies have shown that dexmedetomidine (DXM), a selective α2-adrenoceptor agonist, also has neuroprotective effects.
However, its effect on impaired peripheral nerve regeneration has not been studied.
Materials and Methods.
Forty-five Sprague-Dawley rats were randomly assigned to three groups: group 1 (control SHAM), group 2 (sciatic nerve injury + normal saline), and group 3 (sciatic nerve injury + DXM).
The rats of group 3 were subdivided into the following three groups: DXM 0.5, 6, and 20 μg·kg−1 (groups 3A, 3B, and 3C, resp.).
The sciatic nerve injury was assessed for nerve regeneration at 2 and 6 weeks.
Results.
There were no differences between groups 2 and 3 in their sciatic functional index (SFI) values or histological findings at 2 weeks postinjury.
However, SFI differences were statistically significant at 6 weeks postinjury in group 3.
The gross findings with H&E staining showed that the number of axons was higher in group 3 than in group 2.
There was no histological difference according to the DXM concentration.
Conclusion.
The coincidental functional and histological assessment results of this study suggest that DXM for 6 weeks positively affects damaged peripheral nerves.
American Psychological Association (APA)
Jeong, Wook& Kung, Hsichiang& Cheng, Chia Chi& Lim, Changwoo& Jung, Min Jung& Lee, Jaeho…[et al.]. 2017. Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model. Pain Research and Management،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1197529
Modern Language Association (MLA)
Jeong, Wook…[et al.]. Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model. Pain Research and Management No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1197529
American Medical Association (AMA)
Jeong, Wook& Kung, Hsichiang& Cheng, Chia Chi& Lim, Changwoo& Jung, Min Jung& Lee, Jaeho…[et al.]. Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1197529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197529