Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model

Abstract EN

Background.

Several studies have shown that dexmedetomidine (DXM), a selective α2-adrenoceptor agonist, also has neuroprotective effects.

However, its effect on impaired peripheral nerve regeneration has not been studied.

Materials and Methods.

Forty-five Sprague-Dawley rats were randomly assigned to three groups: group 1 (control SHAM), group 2 (sciatic nerve injury + normal saline), and group 3 (sciatic nerve injury + DXM).

The rats of group 3 were subdivided into the following three groups: DXM 0.5, 6, and 20 μg·kg−1 (groups 3A, 3B, and 3C, resp.).

The sciatic nerve injury was assessed for nerve regeneration at 2 and 6 weeks.

Results.

There were no differences between groups 2 and 3 in their sciatic functional index (SFI) values or histological findings at 2 weeks postinjury.

However, SFI differences were statistically significant at 6 weeks postinjury in group 3.

The gross findings with H&E staining showed that the number of axons was higher in group 3 than in group 2.

There was no histological difference according to the DXM concentration.

Conclusion.

The coincidental functional and histological assessment results of this study suggest that DXM for 6 weeks positively affects damaged peripheral nerves.