Efficacy of Preoperative Administration of Paracetamol-Codeine on Pain following Impacted Mandibular Third Molar Surgery: A Randomized, Split-Mouth, Placebo-Controlled, Double-Blind Clinical Trial
Joint Authors
Annibali, Susanna
La Monaca, Gerardo
Cristalli, Maria Paola
Pranno, Nicola
De Angelis, Chiara
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
The aim of this study was to determine the effectiveness of preoperative administration of single-dose of paracetamol-codeine, in the relieving of acute postoperative pain after the surgical removal of an impacted mandibular third molar.
Materials and Methods.
The study cohort consisted of 32 Caucasian outpatients, giving a total of 64 bilateral symmetrical impacted mandibles.
Patients were randomized in two experimental groups to receive a preoperative oral dose of paracetamol-codeine (analgesic group) or a placebo (placebo group) at the first and second surgeries.
Study participants were asked to record pain intensity scores during the operation and the next 2 days, the time of the first request for rescue analgesic, and the total number of postoperative-supplement paracetamol-codeine tablets.
Results.
The pain intensity score on the first day was significantly lower in the analgesic group than in the placebo group (p<0.001).
The time to using rescue therapy was significantly longer in the analgesic group than in the placebo group (p=0.004).
The number of paracetamol-codeine tablets used postoperatively did not differ between the analgesic and placebo groups (p=0.104).
Conclusions.
Preoperative paracetamol-codeine is effective in providing immediate postoperative pain control after third molar surgery and in delaying the initial onset of pain.
This trial is registered with ClinicalTrials.gov Identifier (Registration Number): NCT03049878.
American Psychological Association (APA)
Cristalli, Maria Paola& La Monaca, Gerardo& De Angelis, Chiara& Pranno, Nicola& Annibali, Susanna. 2017. Efficacy of Preoperative Administration of Paracetamol-Codeine on Pain following Impacted Mandibular Third Molar Surgery: A Randomized, Split-Mouth, Placebo-Controlled, Double-Blind Clinical Trial. Pain Research and Management،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197535
Modern Language Association (MLA)
Cristalli, Maria Paola…[et al.]. Efficacy of Preoperative Administration of Paracetamol-Codeine on Pain following Impacted Mandibular Third Molar Surgery: A Randomized, Split-Mouth, Placebo-Controlled, Double-Blind Clinical Trial. Pain Research and Management No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1197535
American Medical Association (AMA)
Cristalli, Maria Paola& La Monaca, Gerardo& De Angelis, Chiara& Pranno, Nicola& Annibali, Susanna. Efficacy of Preoperative Administration of Paracetamol-Codeine on Pain following Impacted Mandibular Third Molar Surgery: A Randomized, Split-Mouth, Placebo-Controlled, Double-Blind Clinical Trial. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197535