Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites
Joint Authors
Nahar, Lutfun
Pudjiastuti, Pratiwi
Puspaningsih, Ni Nyoman T.
Siswanto, Imam
Fanani, Much. Z.
Ariga, Yoko K.
Hase, Toshiharu
Sarker, Satyajit D.
Source
Journal of Parasitology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Ferredoxin-NADP+ reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for the development of new antimalarial agents.
Croomine, epi-croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of Stemona sp.
and their inhibitory effect on FNRs from Plasmodium falciparum (PfFNR) was investigated.
Croomine showed the highest level of inhibition (33.9%) of electron transfer from PfFNR to PfFd, while tuberstemonine displayed the highest level of inhibition (55.4%) of diaphorase activity of PfFNR.
Docking analysis represented that croomine is located at the middle position of PfFNR and PfFd.
Croomine from S.
tuberosa appeared to have potential as an antimalarial agent.
American Psychological Association (APA)
Pudjiastuti, Pratiwi& Puspaningsih, Ni Nyoman T.& Siswanto, Imam& Fanani, Much. Z.& Ariga, Yoko K.& Hase, Toshiharu…[et al.]. 2018. Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites. Journal of Parasitology Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1197577
Modern Language Association (MLA)
Pudjiastuti, Pratiwi…[et al.]. Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites. Journal of Parasitology Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1197577
American Medical Association (AMA)
Pudjiastuti, Pratiwi& Puspaningsih, Ni Nyoman T.& Siswanto, Imam& Fanani, Much. Z.& Ariga, Yoko K.& Hase, Toshiharu…[et al.]. Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites. Journal of Parasitology Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1197577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197577
