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MR Micro-Neurography and a Segmentation Protocol Applied to Diabetic Neuropathy
Joint Authors
Felisaz, Paolo F.
Balducci, Francesco
Maugeri, Giulia
Calliada, Fabrizio
Baldi, Maurizia
Bastianello, Stefano
Chiovato, Luca
Gitto, Salvatore
Busi, V.
Vitale, R.
Leporati, P.
Pichiecchio, A.
Source
Radiology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to assess with MRI morphometric ultrastructural changes in nerves affected by diabetic peripheral neuropathy (DPN).
We used an MR micro-neurography imaging protocol and a semiautomated technique of tissue segmentation to visualize and measure the volume of internal nerve components, such as the epineurium and nerve fascicles.
The tibial nerves of 16 patients affected by DPN and of 15 healthy volunteers were imaged.
Nerves volume (NV), fascicles volume (FV), fascicles to nerve ratio (FNR), and nerves cross-sectional areas (CSA) were obtained.
In patients with DPN the NV was increased and the FNR was decreased, as a result of an increase of the epineurium (FNR in diabetic neuropathy 0,665; in controls 0,699, p=0,040).
CSA was increased in subjects with DPN (12,84 mm2 versus 10,22 mm2, p=0,003).
The FV was increased in patients with moderate to severe DPN.
We have demonstrated structural changes occurring in nerves affected by DPN, which otherwise are assessable only with an invasive biopsy.
MR micro-neurography appears to be suitable for the study of microscopic changes in tibial nerves of diabetic patients.
American Psychological Association (APA)
Felisaz, Paolo F.& Maugeri, Giulia& Busi, V.& Vitale, R.& Balducci, Francesco& Gitto, Salvatore…[et al.]. 2017. MR Micro-Neurography and a Segmentation Protocol Applied to Diabetic Neuropathy. Radiology Research and Practice،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1197680
Modern Language Association (MLA)
Felisaz, Paolo F.…[et al.]. MR Micro-Neurography and a Segmentation Protocol Applied to Diabetic Neuropathy. Radiology Research and Practice No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1197680
American Medical Association (AMA)
Felisaz, Paolo F.& Maugeri, Giulia& Busi, V.& Vitale, R.& Balducci, Francesco& Gitto, Salvatore…[et al.]. MR Micro-Neurography and a Segmentation Protocol Applied to Diabetic Neuropathy. Radiology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1197680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197680