Evaluation of Quality of Life at Progression in Patients with Soft Tissue Sarcoma
Joint Authors
D’Adamo, David R.
Hudgens, Stacie
Forsythe, Anna
Kontoudis, Ilias
Bird, Ashley
Gelderblom, Hans
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Soft Tissue Sarcoma (STS) is a rare malignancy of mesodermal tissue, with international incidence estimates between 1.8 and 5 per 100,000 per year.
Understanding quality of life (QoL) and the detrimental impact of disease progression is critical for long-term care and survival.
Objectives.
The primary objective was to explore the relationship between disease progression and health-related quality of life (HRQoL) using data from Eisai’s study (E7389-G000-309).
Methods.
This was a 1 : 1 randomized, open-label, multicenter, Phase 3 study comparing the efficacy and safety of eribulin versus dacarbazine in patients with advanced STS.
The QoL analysis was conducted for the baseline and progression populations using the European Organization for Research and Treatment of Cancer 30-item core QoL questionnaire (EORTC QLQ-C30).
Results.
There were no statistical differences between the two treatment arms at baseline for any domain (p>0.05; n=452).
Of the 399 patients who experienced disease progression (unadjusted and adjusting for histology), dacarbazine patients had significantly lower Global Health Status, Physical Functioning scores, and significantly worse Nausea and Vomiting, Insomnia, and Appetite Loss (p<0.05).
Conclusions.
These results indicate differences in HRQoL overall and at progression between dacarbazine and eribulin patients, with increases in symptom severity observed among dacarbazine patients.
American Psychological Association (APA)
Hudgens, Stacie& Forsythe, Anna& Kontoudis, Ilias& D’Adamo, David R.& Bird, Ashley& Gelderblom, Hans. 2017. Evaluation of Quality of Life at Progression in Patients with Soft Tissue Sarcoma. Complexity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197720
Modern Language Association (MLA)
Hudgens, Stacie…[et al.]. Evaluation of Quality of Life at Progression in Patients with Soft Tissue Sarcoma. Complexity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1197720
American Medical Association (AMA)
Hudgens, Stacie& Forsythe, Anna& Kontoudis, Ilias& D’Adamo, David R.& Bird, Ashley& Gelderblom, Hans. Evaluation of Quality of Life at Progression in Patients with Soft Tissue Sarcoma. Complexity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197720