![](/images/graphics-bg.png)
Neoadjuvant Ifosfamide and Epirubicin in the Treatment of Malignant Peripheral Nerve Sheath Tumors
Joint Authors
Dahiya, Sonika
Hirbe, Angela C.
Cosper, Pippa F.
Van Tine, Brian A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Objectives.
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas with poor overall survival.
Response to chemotherapy has been debated for these tumors.
Methods.
We performed a retrospective analysis of the patients at our institution with a biopsy-proven diagnosis of MPNST that underwent neoadjuvant chemotherapy prior to surgery.
Results.
We retrospectively identified five patients who received neoadjuvant chemotherapy with epirubicin and ifosfamide that demonstrated a 30% reduction in tumor growth and a 60% response rate by RECIST criteria.
Additionally, a metabolic response was observed in all three patients who received serial PET scans during neoadjuvant treatment.
The clinical benefit rate, which includes stable disease, was 100%.
Conclusions.
Our data suggest that MPNSTs do respond to epirubicin and ifosfamide based chemotherapy and prospective studies are warranted to further define the clinical benefit.
American Psychological Association (APA)
Hirbe, Angela C.& Cosper, Pippa F.& Dahiya, Sonika& Van Tine, Brian A.. 2017. Neoadjuvant Ifosfamide and Epirubicin in the Treatment of Malignant Peripheral Nerve Sheath Tumors. Complexity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197725
Modern Language Association (MLA)
Hirbe, Angela C.…[et al.]. Neoadjuvant Ifosfamide and Epirubicin in the Treatment of Malignant Peripheral Nerve Sheath Tumors. Complexity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1197725
American Medical Association (AMA)
Hirbe, Angela C.& Cosper, Pippa F.& Dahiya, Sonika& Van Tine, Brian A.. Neoadjuvant Ifosfamide and Epirubicin in the Treatment of Malignant Peripheral Nerve Sheath Tumors. Complexity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197725